Product Name :
Niaprazine
Description:
Niaprazine is a histamine H1-receptor antagonist with marked sedative properties. Niaprazine has antihistamine and antiserotonin activities and can be used for sleep disorder research.
CAS:
27367-90-4
Molecular Weight:
356.44
Formula:
C20H25FN4O
Chemical Name:
N-{4-[4-(4-fluorophenyl)piperazin-1-yl]butan-2-yl}pyridine-3-carboxamide
Smiles :
CC(CCN1CCN(CC1)C1C=CC(F)=CC=1)NC(=O)C1=CN=CC=C1
InChiKey:
RSKQGBFMNPDPLR-UHFFFAOYSA-N
InChi :
InChI=1S/C20H25FN4O/c1-16(23-20(26)17-3-2-9-22-15-17)8-10-24-11-13-25(14-12-24)19-6-4-18(21)5-7-19/h2-7,9,15-16H,8,10-14H2,1H3,(H,23,26)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Niaprazine is a histamine H1-receptor antagonist with marked sedative properties. Niaprazine has antihistamine and antiserotonin activities and can be used for sleep disorder research.|Product information|CAS Number: 27367-90-4|Molecular Weight: 356.44|Formula: C20H25FN4O|Chemical Name: N-{4-[4-(4-fluorophenyl)piperazin-1-yl]butan-2-yl}pyridine-3-carboxamide|Smiles: CC(CCN1CCN(CC1)C1C=CC(F)=CC=1)NC(=O)C1=CN=CC=C1|InChiKey: RSKQGBFMNPDPLR-UHFFFAOYSA-N|InChi: InChI=1S/C20H25FN4O/c1-16(23-20(26)17-3-2-9-22-15-17)8-10-24-11-13-25(14-12-24)19-6-4-18(21)5-7-19/h2-7,9,15-16H,8,10-14H2,1H3,(H,23,26)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 100 mg/mL (280.55 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Amcenestrant} site|{Amcenestrant} Vitamin D Related/Nuclear Receptor|{Amcenestrant} Biological Activity|{Amcenestrant} In stock|{Amcenestrant} supplier|{Amcenestrant} Epigenetic Reader Domain} |Shelf Life: ≥12 months if stored properly.{{Lisaftoclax} medchemexpress|{Lisaftoclax} Apoptosis|{Lisaftoclax} Purity & Documentation|{Lisaftoclax} References|{Lisaftoclax} manufacturer|{Lisaftoclax} Autophagy} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:31899014 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Niaprazine exhibits a low affinity for the vesicular monoamine transporter and for D2, α2, β, H1 and mAch receptors. Niaprazine, particularly the (+)stereoisomer, has a higher affinity for α1 (Ki = 77 nM) and 5-HT2 (Ki = 25 nM) binding sites, but is poorly recognized by 5-HT1A and 5-HT1B binding sites.|In Vivo:|Niaprazine (60 mg/kg; i.p.; once) treatment increases rat brain 5-hydroxyindole acetic acid (5-HIAA) concentrations 30 min after treatment, and reduced them at 3-8 hr after treatment. Niaprazine also produces a short-lasting depletion of rat brain noradrenaline (NA) and dopamine (DA).|Products are for research use only. Not for human use.|
