Product Name :
PD 146176
Description:
PD 146176 is a specific, non-competitve 15-lipoxygenase (15-LOX) inhibitor with Ki of 197 nM.
CAS:
4079-26-9
Molecular Weight:
237.32
Formula:
C15H11NS
Chemical Name:
6,11-dihydro-[1]benzothiopyrano[4,3-b]indole
Smiles :
C1SC2=CC=CC=C2C2NC3=CC=CC=C3C=21
InChiKey:
ZGOOPZVQMLHPFM-UHFFFAOYSA-N
InChi :
InChI=1S/C15H11NS/c1-3-7-13-10(5-1)12-9-17-14-8-4-2-6-11(14)15(12)16-13/h1-8,16H,9H2
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
PD 146176 is a specific, non-competitve 15-lipoxygenase (15-LOX) inhibitor with Ki of 197 nM.|Product information|CAS Number: 4079-26-9|Molecular Weight: 237.32|Formula: C15H11NS|Synonym:|NSC168807|Chemical Name: 6,11-dihydro-[1]benzothiopyrano[4,3-b]indole|Smiles: C1SC2=CC=CC=C2C2NC3=CC=CC=C3C=21|InChiKey: ZGOOPZVQMLHPFM-UHFFFAOYSA-N|InChi: InChI=1S/C15H11NS/c1-3-7-13-10(5-1)12-9-17-14-8-4-2-6-11(14)15(12)16-13/h1-8,16H,9H2|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 25 mg/mL (105.34 mM; Need ultrasonic) H2O : Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|In intact IC21 cells transfected with human 15-LO, PD146176 inhibits 13-HODE production with an IC50 of 0.81 μM.|In Vivo:|PD146176 (80 mg/kg; Chowing; 12 weeks) reverses cognitive impairment, brain amyloidosis, and Tau pathology by stimulating autophagy in aged triple transgenic mice.{{Imatinib} medchemexpress|{Imatinib} Protein Tyrosine Kinase/RTK|{Imatinib} Purity & Documentation|{Imatinib} Data Sheet|{Imatinib} custom synthesis|{Imatinib} Autophagy} |References:|Sendobry SM, et al.{{Biocytin} MedChemExpress|{Biocytin} Metabolic Enzyme/Protease|{Biocytin} TGF-beta/Smad|{Biocytin} Biological Activity|{Biocytin} In stock|{Biocytin} custom synthesis} Attenuation of diet-induced atherosclerosis in rabbits with a highly selective 15-lipoxygenase inhibitor lacking significant antioxidant properties.PMID:34235739 Br J Pharmacol. 1997;120(7):1199-1206.Bocan TM, et al. A specific 15-lipoxygenase inhibitor limits the progression and monocyte-macrophage enrichment of hypercholesterolemia-induced atherosclerosis in the rabbit [published correction appears in Atherosclerosis 1998 Jul;139(1):201]. Atherosclerosis. 1998;136(2):203-216.Di Meco A, et al. 12/15-Lipoxygenase Inhibition Reverses Cognitive Impairment, Brain Amyloidosis, and Tau Pathology by Stimulating Autophagy in Aged Triple Transgenic Mice. Biol Psychiatry. 2017;81(2):92-100.Products are for research use only. Not for human use.|
