Product Name :
Cryptophycin 1
Description:
Cryptophycin 1 is a potent cytotoxic antimicrotubule agent which is isolated from Nostoc sp. Cryptophycin 1 can induce cells apoptosis, and exhibits antitumor activity and exceptional antiproliferative potency.
CAS:
124689-65-2
Molecular Weight:
655.18
Formula:
C35H43ClN2O8
Chemical Name:
(3S,6R,10R,16S)-10-[(3-chloro-4-methoxyphenyl)methyl]-6-methyl-3-(2-methylpropyl)-16-[(1S)-1-[(2R,3R)-3-phenyloxiran-2-yl]ethyl]-1,4-dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone
Smiles :
CC(C)C[C@@H]1OC(=O)[C@H](C)CNC(=O)[C@@H](CC2=CC=C(OC)C(Cl)=C2)NC(=O)C=CC[C@H](OC1=O)[C@H](C)[C@H]1O[C@@H]1C1=CC=CC=C1 |t:29|
InChiKey:
PSNOPSMXOBPNNV-GKPRUIBSSA-N
InChi :
InChI=1S/C35H43ClN2O8/c1-20(2)16-29-35(42)44-27(22(4)31-32(46-31)24-10-7-6-8-11-24)12-9-13-30(39)38-26(33(40)37-19-21(3)34(41)45-29)18-23-14-15-28(43-5)25(36)17-23/h6-11,13-15,17,20-22,26-27,29,31-32H,12,16,18-19H2,1-5H3,(H,37,40)(H,38,39)/b13-9-/t21-,22+,26-,27+,29+,31-,32-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Cryptophycin 1 is a potent cytotoxic antimicrotubule agent which is isolated from Nostoc sp. Cryptophycin 1 can induce cells apoptosis, and exhibits antitumor activity and exceptional antiproliferative potency.|Product information|CAS Number: 124689-65-2|Molecular Weight: 655.18|Formula: C35H43ClN2O8|Chemical Name: (3S,6R,10R,16S)-10-[(3-chloro-4-methoxyphenyl)methyl]-6-methyl-3-(2-methylpropyl)-16-[(1S)-1-[(2R,3R)-3-phenyloxiran-2-yl]ethyl]-1,4-dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone|Smiles: CC(C)C[C@@H]1OC(=O)[C@H](C)CNC(=O)[C@@H](CC2=CC=C(OC)C(Cl)=C2)NC(=O)C=CC[C@H](OC1=O)[C@H](C)[C@H]1O[C@@H]1C1=CC=CC=C1 |t:29||InChiKey: PSNOPSMXOBPNNV-GKPRUIBSSA-N|InChi: InChI=1S/C35H43ClN2O8/c1-20(2)16-29-35(42)44-27(22(4)31-32(46-31)24-10-7-6-8-11-24)12-9-13-30(39)38-26(33(40)37-19-21(3)34(41)45-29)18-23-14-15-28(43-5)25(36)17-23/h6-11,13-15,17,20-22,26-27,29,31-32H,12,16,18-19H2,1-5H3,(H,37,40)(H,38,39)/b13-9-/t21-,22+,26-,27+,29+,31-,32-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Nemvaleukin alfa} site|{Nemvaleukin alfa} Interleukin Related|{Nemvaleukin alfa} Protocol|{Nemvaleukin alfa} Description|{Nemvaleukin alfa} custom synthesis|{Nemvaleukin alfa} Autophagy} |Shelf Life: ≥12 months if stored properly.{{Asfotase alfa} MedChemExpress|{Asfotase alfa} Protocol|{Asfotase alfa} Description|{Asfotase alfa} custom synthesis|{Asfotase alfa} Epigenetics} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:22943596 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Cryptophycin 1 (50 pM) rapidly causes morphological changes consistent with the induction of apoptosis in SKOV3 and MDA-MB-435 cells. Cryptophycin 1 (50 pM; 12-24 h) causes an accumulation of MDA-MB-435 cells in G2/M. Cryptophycin 1 (100 nM; 1-7 min) markedly reduces the rates and extents of microtubule shortening and growing events and dramatically increases the duration of phases of attenuation or pause.|In Vivo:|Cryptophycin 1 (i.v.) exhibits anti-tumor activity in mice.|Products are for research use only. Not for human use.|
