Product Name :
Evodiamine
Description:
Evodiamine is an alkaloid isolated from the fruit of Evodia rutaecarpa Bentham with diverse biological activities including anti-inflammatory, anti-obesity, and antitumor.
CAS:
518-17-2
Molecular Weight:
303.36
Formula:
C19H17N3O
Chemical Name:
(1S)-21-methyl-3,13,21-triazapentacyclo[11.8.0.0²,¹⁰.0⁴,⁹.0¹⁵,²⁰]henicosa-2(10),4,6,8,15,17,19-heptaen-14-one
Smiles :
CN1[C@@H]2C3NC4=CC=CC=C4C=3CCN2C(=O)C2=CC=CC=C12
InChiKey:
TXDUTHBFYKGSAH-SFHVURJKSA-N
InChi :
InChI=1S/C19H17N3O/c1-21-16-9-5-3-7-14(16)19(23)22-11-10-13-12-6-2-4-8-15(12)20-17(13)18(21)22/h2-9,18,20H,10-11H2,1H3/t18-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Evodiamine is an alkaloid isolated from the fruit of Evodia rutaecarpa Bentham with diverse biological activities including anti-inflammatory, anti-obesity, and antitumor.|Product information|CAS Number: 518-17-2|Molecular Weight: 303.36|Formula: C19H17N3O|Chemical Name: (1S)-21-methyl-3,13,21-triazapentacyclo[11.8.0.0²,¹⁰.0⁴,⁹.0¹⁵,²⁰]henicosa-2(10),4,6,8,15,17,19-heptaen-14-one|Smiles: CN1[C@@H]2C3NC4=CC=CC=C4C=3CCN2C(=O)C2=CC=CC=C12|InChiKey: TXDUTHBFYKGSAH-SFHVURJKSA-N|InChi: InChI=1S/C19H17N3O/c1-21-16-9-5-3-7-14(16)19(23)22-11-10-13-12-6-2-4-8-15(12)20-17(13)18(21)22/h2-9,18,20H,10-11H2,1H3/t18-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 10 mg/mL (32.96 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.{{DAMGO} MedChemExpress|{DAMGO} GPCR/G Protein|{DAMGO} Immunology/Inflammation|{DAMGO} Biological Activity|{DAMGO} Description|{DAMGO} custom synthesis} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Evodiamine shows cytotoxicity against a variety of human cancer cell-lines by inducing apoptosis. Moreover, it is a naturally multi-targeting antitumor molecule, which exerts the antitumor activity by various molecular mechanism such as caspase-dependent and -independent pathways, sphingomyelin pathway, calcium/JNK signaling, 31 PI3K/Akt/caspase and Fas-L/NF-κB signaling pathways32.{{BCMA/TNFRSF17 Protein, Human} medchemexpress|{BCMA/TNFRSF17 Protein, Human} Biological Activity|{BCMA/TNFRSF17 Protein, Human} Formula|{BCMA/TNFRSF17 Protein, Human} manufacturer|{BCMA/TNFRSF17 Protein, Human} Cancer} |In Vivo:|Evodiamine inhibits the metabolism of dapoxetine.PMID:23381601 Compared to the control group, the pharmacokinetic parameter of t1/2, AUC(0-∞) and Tmax of dapoxetine in evodiamine group is significantly increased by 63.3%, 44.8% and 50.4%, respectively. Moreover, evodiamine has significantly decreased the pharmacokinetic parameter of t1/2 and AUC(0-∞) of desmethyl dapoxetine. Evodiamine suppresses tumor growth in a subcutaneous H22 xenograft model. Evodiamine attenuates VEGF-induced angiogenesis in vivo.|Products are for research use only. Not for human use.|
