Product Name :
ML-031
Description:
ML-031 is an agonist of S1P2 with EC50 value of 1 μM . Sphingosine 1-phosphate (S1P) is a bioactive lysophospholipid mediator mainly released from activated platelets and implicated in many biological responses, such as cell proliferation, migration, survival, and differentiation . Sphingolipids belong to a family of bioactive molecules with cell signaling properties. Sphingosine 1-phosphate (S1P) is widely expressed on various tissues and cell types. S1P is a pleiotropic lysophospholipid mediator exists in plasma and is released in large amounts from activated platelets . Until now, five sphingosine-1-phosphate receptors (S1PR1-S1PR5) have been identified. S1PR4 and S1PR5 are prominently expressed in the immune and nervous systems, respectively. S1P functions by binding to five distinct G protein-coupled receptors, S1P1/EDG-1, S1P2/EDG-5, S1P3/EDG-3, S1P4/EDG-6, and S1P5/EDG-8. ML-031 activated S1P2 with an EC50 value of 1 μM in a S1P reporter assay .
CAS:
852230-33-2
Molecular Weight:
324.37
Formula:
C19H20N2O3
Chemical Name:
1-[2-(1-benzyl-2,5-dimethyl-1H-pyrrol-3-yl)-2-oxoethyl]pyrrolidine-2,5-dione
Smiles :
CC1=C(C=C(C)N1CC1C=CC=CC=1)C(=O)CN1C(=O)CCC1=O
InChiKey:
JRESCQKIRPOOEM-UHFFFAOYSA-N
InChi :
InChI=1S/C19H20N2O3/c1-13-10-16(17(22)12-21-18(23)8-9-19(21)24)14(2)20(13)11-15-6-4-3-5-7-15/h3-7,10H,8-9,11-12H2,1-2H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
ML-031 is an agonist of S1P2 with EC50 value of 1 μM . Sphingosine 1-phosphate (S1P) is a bioactive lysophospholipid mediator mainly released from activated platelets and implicated in many biological responses, such as cell proliferation, migration, survival, and differentiation . Sphingolipids belong to a family of bioactive molecules with cell signaling properties.{{B-Raf IN 2} MedChemExpress|{B-Raf IN 2} MAPK/ERK Pathway|{B-Raf IN 2} Protocol|{B-Raf IN 2} References|{B-Raf IN 2} custom synthesis|{B-Raf IN 2} Epigenetics} Sphingosine 1-phosphate (S1P) is widely expressed on various tissues and cell types.{{Phorbol 12-myristate 13-acetate} MedChemExpress|{Phorbol 12-myristate 13-acetate} Immunology/Inflammation|{Phorbol 12-myristate 13-acetate} Protocol|{Phorbol 12-myristate 13-acetate} Data Sheet|{Phorbol 12-myristate 13-acetate} manufacturer|{Phorbol 12-myristate 13-acetate} Cancer} S1P is a pleiotropic lysophospholipid mediator exists in plasma and is released in large amounts from activated platelets .PMID:36014399 Until now, five sphingosine-1-phosphate receptors (S1PR1-S1PR5) have been identified. S1PR4 and S1PR5 are prominently expressed in the immune and nervous systems, respectively. S1P functions by binding to five distinct G protein-coupled receptors, S1P1/EDG-1, S1P2/EDG-5, S1P3/EDG-3, S1P4/EDG-6, and S1P5/EDG-8. ML-031 activated S1P2 with an EC50 value of 1 μM in a S1P reporter assay .|Product information|CAS Number: 852230-33-2|Molecular Weight: 324.37|Formula: C19H20N2O3|Chemical Name: 1-[2-(1-benzyl-2,5-dimethyl-1H-pyrrol-3-yl)-2-oxoethyl]pyrrolidine-2,5-dione|Smiles: CC1=C(C=C(C)N1CC1C=CC=CC=1)C(=O)CN1C(=O)CCC1=O|InChiKey: JRESCQKIRPOOEM-UHFFFAOYSA-N|InChi: InChI=1S/C19H20N2O3/c1-13-10-16(17(22)12-21-18(23)8-9-19(21)24)14(2)20(13)11-15-6-4-3-5-7-15/h3-7,10H,8-9,11-12H2,1-2H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
