And necessitates the development of novel therapeutics that will: (1) lower the reliance on b-agonists by potentiating their bronchodilating effects at lower helpful concentrations; and (two) work to unwind ASMAmerican Journal of Respiratory Cell and Molecular Biology Volume 50 Quantity 1 | JanuaryORIGINAL RESEARCHby complementary yet option signaling pathways. We have shown that active elements of ginger can reach both of those objectives by inhibiting cAMP degradation in ASM, preventing IP3 and DAG generation, and thereby modulating accessory proteins that regulate contractile machinery inside the cell. This has the potential to decrease reliance on b-agonists and enable preserve b2-AR expression and activity in the airway. Dixon and Santana (40) lately asked the question, “does inhibition of PKC in ASM improve airflow in the course of asthma and COPD?” Our existing data, with each other with our prior in vivo research (9), argue that this can be a prospective signaling mechanism to explain the bronchorelaxant properties of 6-gingerol, 8-gingerol, and 6-shogaol, and could prove a yet-unrealized target for future asthma therapies. nAuthor disclosures are available with all the text of this short article at atsjournals.org. Acknowledgments: The authors thank Dr. William Gerthoffer for the generous present of immortalized human airway smooth muscle cells.
HHS Public AccessAuthor manuscriptArthritis Rheum. Author manuscript; offered in PMC 2015 March 18.Published in final edited form as: Arthritis Rheum. 2013 Could ; 65(5): 1181?193. doi:10.1002/art.37894.Author Manuscript Author Manuscript Author Manuscript Author ManuscriptAdoptive transfer of human gingiva-derived mesenchymal stem cells ameliorates PPARβ/δ Activator Purity & Documentation collagen-induced arthritis by way of suppressing Th1 and Th17 and enhancing regulatory T cell differentiationMaogen Chen1,two, Wenru Su3, Xiaohong Lin2,four, Zhiyong Guo1, Julie Wang2, Qunzhou Zhang3, David Brand5, Bernhard Ryffel6, Jiefu Huang1, Zhongmin Liu7, Xiaoshun He1,, Anh D. Le3, and Song Guo Zheng2,7,1OrganTransplant center, 1st affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, P.R. China2Divisionof Rheumatology and Immunology, Department of Medicine, University of Southern California, Keck College of Medicine, Los Angeles, CA. 90033, USA3Divisionof Surgical, Therapeutic and Bioengineering Sciences, Center for Craniofacial Molecular Biology, University of Southern California, Keck College of Medicine, Los Angeles, CA. 90033, USA of Surgery, Initially affiliated Hospital of Shantou University, Shantou, 515041 China Service, Veterans Affairs Medical Center, Memphis; TN. 38104, USA4Division5Research6UMR6218,Molecular Immunology, University and CNRS, 3b rue de la Ferollerie, Orleans. 45071, France of Immunology, Shanghai East Hospital at Tongji University, Shanghai, 200120, China7InstituteAbstractObjective–Current approaches supply no cures for rheumatoid arthritis (RA). Accumulating evidence has revealed that manipulation of bone-marrow mesenchymal stem cells (BMSCs) might possess the potential to treat RA. Though BMSC-based therapy faces a lot of challenges like Macrolide Inhibitor Formulation limited cell availability and decreased clinical feasibility, we herein demonstrate that substitution of gingival-derived mesenchymal stem cells (GMSCs) results in considerably enhanced therapeutic effects on established collagen-induced arthritis (CIA).Address correspondence and reprint requests to Song Guo Zheng, MD, PhD, Division of Rheumatology and Immunology, University of Southern California, 2011 Zonal Ave.
