thods: A retrospective study of 146 files of patients with thromboembolic venous disease over a 5-year period (2013017). Final results: Twenty-one cases (14.3 )had uncommon web sites venous thrombosis: 9men and 12women with an typical age of 37.1years. DVT of your abdominal veins was dominant observed in 8patients with 1case of portal thrombosis, 1case of splenic venous thrombosis, 4cases of854 of|ABSTRACTmesenteric venous thrombosis, 1case from the renal vein, and 4cases in the ovarian vein. DVT in the inferior vena cava was observed in 6patients, that on the cerebral veins in 2cases and that of the upper limbs in 1case. Threat variables for abdominal venous thrombosis had been dominated by intra-abdominal surgery (4cases), cirrhosis with portal hypertension (2cases), inflammatory bole disease (2cases) as well as a history of thrombosis (4cases). The other venous thrombosis of uncommon web page had occurred following bed rest (7 circumstances), surgery (6cases), post partum (5 cases) and in the context of Beh t’s disease in 1case. An etiological assessment, carried out in all instances had shown that constitutional thrombophilia was observed in 10patients (47.six ), dominated by resistance to activated protein C (APCR). (APCR) was isolated in 8cases, associated with protein S deficiency in 1case and antiphospholipid syndrome in 1 case. Unusual venous thromboses connected with RPCA were located within the abdominal veins in 4cases, the inferior vena cava in 3 cases and the ovarian veins in three cases. Acquired thrombophilia (antiphospholipid syndrome) was observed in 4patients (19 ). Conclusions: Thrombophlebitis with uncommon localisation can be a severe condition that demands exploration and adequate symptomatic and etiological management.PB1166|Incidence of Thrombosis in Patients with MTHFR C677T Homozygosity and Hyperhomocysteinemia G.M. Nicol; G. Sottilotta2; F. Luise3; V. Oriana2; A. PiromalliClinical Pathology and Clinical Biochemistry, University of Catania,Catania, Italy; 2Hemophilia Centre – Thrombosis and Hemostasis Service, Excellent Metropolitan Hospital, Reggio Calabria, Italy; 3Analysis Laboratory, Wonderful Metropolitan Hospital, Reggio Calabria, Italy Background: Methylene tetrahydrofolate reductase (MTHFR) is really a key enzyme in homocysteine (HCY) metabolism. Previous studies have demonstrated that homozygosis for the MTHFR C677T mutation is connected with an improved threat of thrombosis, even within the absence of hyperhomocysteinemia (hHCY). Having said that, this partnership remains controversial. Aims: To identify the incidence of thrombosis in patients homozygous for C677T MTHFR mutation, with or without having hHCY, in comparison to healthy individuals using the exact same characteristic; we divided the sufferers into two groups: these with typical HCY levels and these with hHCY, assessing the incidence of thrombosis in each groups. The information obtained from the two ERK5 Inhibitor drug groups had been analyzed JAK Inhibitor MedChemExpress working with chisquare test Procedures: We retrospectively analysed the clinical information of 570 subjects with homozygosity for the C677T MTHFR mutation followed by our centre within the last ten years: 149 males, 421 females; typical age: 39.7 (48). 382 had typical HCY and 188 had hHCY. All subjects with other congenital or acquired thrombophilia states had been excluded from the study. hHCY has been defined if greater than 15 micromol/L. Benefits:Table 1 Incidence of thrombosis in homozygous C677T MTHFR individuals with and with no hyperhomocysteinemia.Homozygous C677T MTHFR individuals with thrombosis Regular Homocysteine (15 micromol/L) and (n = 382) Higher H
