Din-2(1H)-one system This second strategy method (Figure 7). In the case thethe CHO group, there [79],761,6-naphthyridin-2(1H)-one group. (Figure 7). In the case of CN group (4 patents) are and 5 references use a ketone [77,78], 12 12 references for references (50 of them patents) [77,78], of the CHO group, you’ll find 76 references (50 of of them patents) [77,78], references for the them patents) of primarily utilized when the final76 references (50 will be the CHO group, there are actually 1,6-naphthyridin-2(1H)-one 13 is just not This 12 references for the group (4 group. bearing any strategy second substituCN CN group (four patents) [79], and 5 references use a ketone group. the CN grouppatents) [79], and five references use a ketone group. This second approach is ent at N1 (R1 =(four patents) [79], and five references use a ketone13 is notThis second method H). is mainly utilized when the final 1,6-naphthyridin-2(1H)-one bearing any substitumainly used when the final 1,6-naphthyridin-2(1H)-one 13 is just isn’t bearing any substituis primarily applied when the final 1,6-naphthyridin-2(1H)-one 13 not bearing any substituent ent at (R1 = H). H). N1 (R11 = at N1 ent at N1 (R = H).Figure 7. Synthetic approach for 1,6-naphthyridin-2(1H)-one (13) from a preformed WZ8040 supplier 4-aminopyridine (23). 7. Synthetic strategy for 1,6-naphthyridin-2(1H)-one (13) from a 4-aminopyridine (23). Figure 7. Synthetic strategy for 1,6-naphthyridin-2(1H)-one (13) from a preformed preformed 4-aminoFigure 7. Synthetic strategy for 1,6-naphthyridin-2(1H)-one (13) from a preformed 4-aminopyridine (23). pyridine (23). An Cholesteryl sulfate Metabolic Enzyme/Protease instance of the use ofof 4-aminonicotinaldehyde will be the the formation of 26 upon An instance with the use a a 4-aminonicotinaldehyde is formation of 26 upon con-densation of 24 together with the use of a 4-aminonicotinaldehyde is the formation (26) in theinconcondensation of 24 with malonamide 25 to afford 1,6-naphthyridin-2(1H)-one (26) presAn example of malonamide 25 to afford 1,6-naphthyridin-2(1H)-one of 26 upon the ence Anpiperidine and EtOH EtOH (Scheme three). typethiscondensation, dimethyl upon presof instance from the use of a 4-aminonicotinaldehydetype of condensation, malonate, presence of piperidine and (Scheme three). In this In of is definitely the formation of 26in the condensation of 24 with malonamide 25 to afford 1,6-naphthyridin-2(1H)-one (26) dimethyl densation of 24 with malonamidemetyl afford 1,6-naphthyridin-2(1H)-one usedin the pres(26) methyl piperidinecyanocetate, or 25 to3). Within this kind of condensation, dimethylduring formalonate, methyl and EtOH (Scheme phenylacetate can alternatively be throughout the the ence of cyanocetate, or metyl phenylacetate can alternatively be utilised malonate, ence of piperidine andsystem(Scheme 3). Within this kind of condensation, dimethyl malonate, EtOH [78]. mation of thethe bicyclic metyl phenylacetate can alternatively be used during the forformation of bicyclic or technique [78]. methyl cyanocetate, methyl cyanocetate, or metyl phenylacetate can alternatively be used during the formation in the bicyclic method [78]. mation on the bicyclic method [78].Scheme three. Synthesis of 1,6-naphthyridin-2(1H)-one (26) from 4-aminonicotinaldehyde (24). Scheme 3. Synthesis of 1,6-naphthyridin-2(1H)-one (26) from 4-aminonicotinaldehyde (24). Scheme 3. Synthesis of 1,6-naphthyridin-2(1H)-one (26) from 4-aminonicotinaldehyde (24).the 1,6Scheme four shows the use of 4-aminonicotinonitrile (27) within the formation ofnaphthyridin-2(1H)-one. Within this example, the condensation among 27 and diethyl malonate (28) in NaOEt i.
