Product Name :
KF21213
Description:
KF21213 is a highly selective ligand for mapping CNS adenosine A2A receptors. KF21213 shows a high affinity for the adenosine A2A receptors (Ki=3.0 nM).
CAS:
155271-17-3
Molecular Weight:
354.40
Formula:
C19H22N4O3
Chemical Name:
8-[(E)-2-(4-methoxy-2,3-dimethylphenyl)ethenyl]-1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione
Smiles :
COC1=CC=C(/C=C/C2=NC3=C(C(=O)N(C)C(=O)N3C)N2C)C(C)=C1C
InChiKey:
SDHWMROLJYZHCX-CSKARUKUSA-N
InChi :
InChI=1S/C19H22N4O3/c1-11-12(2)14(26-6)9-7-13(11)8-10-15-20-17-16(21(15)3)18(24)23(5)19(25)22(17)4/h7-10H,1-6H3/b10-8+
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
KF21213 is a highly selective ligand for mapping CNS adenosine A2A receptors. KF21213 shows a high affinity for the adenosine A2A receptors (Ki=3.0 nM).|Product information|CAS Number: 155271-17-3|Molecular Weight: 354.40|Formula: C19H22N4O3|Chemical Name: 8-[(E)-2-(4-methoxy-2,3-dimethylphenyl)ethenyl]-1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione|Smiles: COC1=CC=C(/C=C/C2=NC3=C(C(=O)N(C)C(=O)N3C)N2C)C(C)=C1C|InChiKey: SDHWMROLJYZHCX-CSKARUKUSA-N|InChi: InChI=1S/C19H22N4O3/c1-11-12(2)14(26-6)9-7-13(11)8-10-15-20-17-16(21(15)3)18(24)23(5)19(25)22(17)4/h7-10H,1-6H3/b10-8+|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Vaborbactam Autophagy |Shelf Life: ≥12 months if stored properly.FMK-MEA MAPK/ERK Pathway |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32930942 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|[11C]KF21213 as a PET ligand for mapping adenosine A2A receptors in the central nervous system (CNS). KF21213 shows a high affinity for the adenosine A2A receptors in vitro (Ki=3.0 nM) and a very low affinity for the A1 receptors (Ki>10,000 nM).|In Vivo:|The uptake of [11C]KF21213 by the striatum gradually increases for the first 15 min and then decreases. The uptake by the cortex and cerebellum is rapidly decreased after injection. Their levels are compatible with that in the blood. Consequently, the uptake ratios of striatum to cortex and striatum to cerebellum increases up to 8.6±1.6 and 10.5±2.1 (N=4), respectively, by 60 min. The striatal activity level of [11C]KF21213 is retained for the initial 5 min and then gradually decreased with time, whereas that of [11C]KF18446 rapidly decreases.The cerebellar activity of the two ligands rapidly decreases.The striatum-to-cerebellum uptake ratio for [11C]KF21213 gradually increases to 2.4 6 0.5 (N 5 3) by 50-60 min, whereas that for [11C]KF18446 increases for the first 10 min and remains constant (1.4±0.3, N=3, at 25-35 min).|Products are for research use only. Not for human use.|
