Product Name :
Integrin modulator 1
Description:
Integrin modulator 1 is a potent and selective α4β1 integrin agonist, with an IC50 of 9.8 nM for RGD-binding α4β1. Integrin modulator 1 increases cell adhesion mediated by α4β1 integrin, with an EC50 of 12.9 nM.
CAS:
2023788-32-9
Molecular Weight:
262.26
Formula:
C13H14N2O4
Chemical Name:
2-1-[(2-methylphenyl)carbamoyl]-4-oxoazetidin-2-ylacetic acid
Smiles :
CC1=CC=CC=C1NC(=O)N1C(CC1=O)CC(O)=O
InChiKey:
NMHXECODTXNHIV-UHFFFAOYSA-N
InChi :
InChI=1S/C13H14N2O4/c1-8-4-2-3-5-10(8)14-13(19)15-9(6-11(15)16)7-12(17)18/h2-5,9H,6-7H2,1H3,(H,14,19)(H,17,18)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.Tofacitinib Purity & Documentation
Additional information:
Integrin modulator 1 is a potent and selective α4β1 integrin agonist, with an IC50 of 9.Bezafibrate Cell Cycle/DNA Damage 8 nM for RGD-binding α4β1. Integrin modulator 1 increases cell adhesion mediated by α4β1 integrin, with an EC50 of 12.9 nM.|Product information|CAS Number: 2023788-32-9|Molecular Weight: 262.26|Formula: C13H14N2O4|Chemical Name: 2-1-[(2-methylphenyl)carbamoyl]-4-oxoazetidin-2-ylacetic acid|Smiles: CC1=CC=CC=C1NC(=O)N1C(CC1=O)CC(O)=O|InChiKey: NMHXECODTXNHIV-UHFFFAOYSA-N|InChi: InChI=1S/C13H14N2O4/c1-8-4-2-3-5-10(8)14-13(19)15-9(6-11(15)16)7-12(17)18/h2-5,9H,6-7H2,1H3,(H,14,19)(H,17,18)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 100 mg/mL (381.PMID:33043694 30 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Integrin modulator 1 (2-10 μg/mL; 30 min) significantly increases Jurkat E6.1 cell adhesion. Integrin modulator 1 (1-100 nM; 1 h) strongly and significantly increases ERK1/2 phosphorylation in Jurkat E6.1 cells. Integrin modulator 1 (1 nM-10 μM; 30 min) significantly increases the binding of HUTS-21 antibody to Jurkat E6.1 cells in a concentration-dependent manner.|References:|Baiula M, et, al. New β-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins. J Med Chem. 2016 Nov 10;59(21):9721-9742.Products are for research use only. Not for human use.|
