Product Name :
Pinacidil monohydrate
Description:
Pinacidil monohydrate, an antihypertensive drug, is a potassium channel activator.
CAS:
85371-64-8
Molecular Weight:
263.34
Formula:
C13H21N5O
Chemical Name:
(Z)-N’-cyano-N-(3,3-dimethylbutan-2-yl)-N”-(pyridin-4-yl)guanidine; (hydrogeniooxy)hydrogen
Smiles :
O.CC(N/C(/NC#N)=N/C1C=CN=CC=1)C(C)(C)C
InChiKey:
AFJCNBBHEVLGCZ-UHFFFAOYSA-N
InChi :
InChI=1S/C13H19N5.H2O/c1-10(13(2,3)4)17-12(16-9-14)18-11-5-7-15-8-6-11;/h5-8,10H,1-4H3,(H2,15,16,17,18);1H2
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Pinacidil monohydrate, an antihypertensive drug, is a potassium channel activator.|Product information|CAS Number: 85371-64-8|Molecular Weight: 263.34|Formula: C13H21N5O|Chemical Name: (Z)-N’-cyano-N-(3,3-dimethylbutan-2-yl)-N”-(pyridin-4-yl)guanidine; (hydrogeniooxy)hydrogen|Smiles: O.CC(N/C(/NC#N)=N/C1C=CN=CC=1)C(C)(C)C|InChiKey: AFJCNBBHEVLGCZ-UHFFFAOYSA-N|InChi: InChI=1S/C13H19N5.H2O/c1-10(13(2,3)4)17-12(16-9-14)18-11-5-7-15-8-6-11;/h5-8,10H,1-4H3,(H2,15,16,17,18);1H2|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 100 mg/mL (379.74 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.BS3 Crosslinker In stock |Shelf Life: ≥12 months if stored properly.Tirabrutinib Apoptosis |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:33016176 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Pinacidil monohydrate is a potassium channel activator. Pinacidil hydrate is an antihypertensive drug of the class of agents called “potassium channel openers”. Pinacidil hydrate activates the ATP-modulated potassium channels of guinea pog bladder and heart with Ki values of 104 and 251 nM, respectively.|References:|Buckle DR, et al. Relaxant effects of the potassium channel activators BRL 38227 and pinacidil on guinea-pig and human airway smooth muscle, and blockade of their effects by glibenclamide and BRL 31660. Pulm Pharmacol. 1993 Mar;6(1):77-86.Bareggi SR, et al. Pharmacodynamics and pharmacokinetics of pinacidil in normotensive volunteers after repeated doses of a new slow-release tablet formulation. Arzneimittelforschung. 1999 Jan;49(1):21-5.Gollasch M, et al. Pinacidil relaxes porcine and human coronary arteries by activating ATP-dependent potassium channels in smooth muscle cells. J Pharmacol Exp Ther. 1995 Nov;275(2):681-92.Products are for research use only. Not for human use.|
