Product Name :
GSK621
Description:
GSK621 is a specific AMPK activator, with IC50 values of 13-30 μM for AML cells. GSK621 induces autophagy and apoptosis. GSK621 induces eiF2α phosphorylation-a hallmark of UPR activation.
CAS:
1346607-05-3
Molecular Weight:
489.91
Formula:
C26H20ClN3O5
Chemical Name:
6-chloro-5-{2′-hydroxy-3′-methoxy-[1, 1′-biphenyl]-4-yl}-3-(3-methoxyphenyl)-1H, 2H, 3H, 4H, 5H-pyrrolo[3, 2-d]pyrimidine-2, 4-dione
Smiles :
COC1=CC(=CC=C1)N1C(=O)NC2C=C(Cl)N(C=2C1=O)C1C=CC(=CC=1)C1=CC=CC(OC)=C1O
InChiKey:
KURYSXLJGKKDHT-UHFFFAOYSA-N
InChi :
InChI=1S/C26H20ClN3O5/c1-34-18-6-3-5-17(13-18)30-25(32)23-20(28-26(30)33)14-22(27)29(23)16-11-9-15(10-12-16)19-7-4-8-21(35-2)24(19)31/h3-14,31H,1-2H3,(H,28,33)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
GSK621 is a specific AMPK activator, with IC50 values of 13-30 μM for AML cells. GSK621 induces autophagy and apoptosis. GSK621 induces eiF2α phosphorylation-a hallmark of UPR activation.{{Glatiramer} web|{Glatiramer} Protocol|{Glatiramer} Formula|{Glatiramer} custom synthesis|{Glatiramer} Cancer} |Product information|CAS Number: 1346607-05-3|Molecular Weight: 489.{{7α-Hydroxycholesterol} site|{7α-Hydroxycholesterol} Purity & Documentation|{7α-Hydroxycholesterol} References|{7α-Hydroxycholesterol} custom synthesis|{7α-Hydroxycholesterol} Epigenetics} 91|Formula: C26H20ClN3O5|Chemical Name: 6-chloro-5-{2′-hydroxy-3′-methoxy-[1, 1′-biphenyl]-4-yl}-3-(3-methoxyphenyl)-1H, 2H, 3H, 4H, 5H-pyrrolo[3, 2-d]pyrimidine-2, 4-dione|Smiles: COC1=CC(=CC=C1)N1C(=O)NC2C=C(Cl)N(C=2C1=O)C1C=CC(=CC=1)C1=CC=CC(OC)=C1O|InChiKey: KURYSXLJGKKDHT-UHFFFAOYSA-N|InChi: InChI=1S/C26H20ClN3O5/c1-34-18-6-3-5-17(13-18)30-25(32)23-20(28-26(30)33)14-22(27)29(23)16-11-9-15(10-12-16)19-7-4-8-21(35-2)24(19)31/h3-14,31H,1-2H3,(H,28,33)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 12.PMID:33023417 5 mg/mL (25.51 mM; ultrasonic and adjust pH to 1 with HCl)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|GSK621 (30 μM) induces AMPKα T172, ACC (S79) and ULK1 (S555) phosphorylation. GSK621 (30 μM) induces autophagy and apoptosis. GSK621 treatment also induces PERK phosphorylation, a marker of ER stress, in AML cells.|In Vivo:|GSK621 (30 mg/kg, ip twice daily) exhibits significant anti-tumor activity in MOLM-14 cells xenograft.|References:|Pierre Sujobert, et al. Co-activation of AMPK and mTORC1 Induces Cytotoxicity in Acute Myeloid Leukemia. Cell Rep. 2015 Jun 9;11(9):1446-57.Products are for research use only. Not for human use.|
