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Phosphoserine polyclonal antibody
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Protein phosphorylation is a complex biochemical process that is regulated by protein kinases that catalyze the transfer of the gamma-P of ATP to a recipient protein that acts as a substrate. This post-translational modification is primarily directed onto serine, threonine, and tyrosine amino acid residues within a protein. Changes in the phosphorylation status of phosphoproteins can alter their biological function, and aberrations in signal transduction cascades have been linked to a number of diseases, including cancer, diabetes, heart disease, inflammation and neurological disorders. Western blot analysis of human MMRU melanoma cells probed with Phosphoserine, pAb. Top (from the left): MMRU cells treated with 0 (A), 50 (B), 200 (C), 400 (D) l long wavelength UV, or 0.1µM of okadaic acid (E). Bottom: Same samples probed with β-actin antibody (control). Western blot analysis of human MMRU melanoma cells probed with Phosphoserine, pAb. Top (from the left): MMRU cells treated with 0 (A), 50 (B), 200 (C), 400 (D) l long wavelength UV, or 0.1µM of okadaic acid (E). Bottom: Same samples probed with β-actin antibody (control).
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| Application ELISA, IHC, IP, WB | Formulation Liquid.{{14003-96-4} medchemexpress|{14003-96-4} Biological Activity|{14003-96-4} Description|{14003-96-4} custom synthesis} In PBS with 50% glycerol.{{2229974-83-6} medchemexpress|{2229974-83-6} Purity & Documentation|{2229974-83-6} References|{2229974-83-6} manufacturer} | Host Rabbit | Immunogen Phosphoserine conjugated to KLH.PMID:30480963 | Recommendation Dilutions/Conditions ELISA (1µg/ml)Immunohistochemistry (5µg/ml)Immunoprecipitation (10µg/mg protein)Western Blot (1µg/ml)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application. | Species Reactivity Species independent | Unit of Measure (UM) µg