Product Name :
Glucokinase activator 1
Description:
Glucokinase activator 1 is a liver-directed glucokinase activator with an EC50 of 34 nM.
CAS:
1328987-85-4
Molecular Weight:
586.58
Formula:
C27H20F2N2O7S2
Chemical Name:
4-({2-[(2R)-2-[4-(cyclopropanesulfonyl)phenyl]-2-(2,4-difluorophenoxy)acetamido]-1,3-thiazol-5-yl}oxy)benzoic acid
Smiles :
OC(=O)C1C=CC(=CC=1)OC1=CN=C(NC(=O)[C@H](OC2=CC=C(F)C=C2F)C2C=CC(=CC=2)S(=O)(=O)C2CC2)S1
InChiKey:
XJFUEUNGZVAEIX-XMMPIXPASA-N
InChi :
InChI=1S/C27H20F2N2O7S2/c28-17-5-12-22(21(29)13-17)38-24(15-3-8-19(9-4-15)40(35,36)20-10-11-20)25(32)31-27-30-14-23(39-27)37-18-6-1-16(2-7-18)26(33)34/h1-9,12-14,20,24H,10-11H2,(H,33,34)(H,30,31,32)/t24-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Glucokinase activator 1 is a liver-directed glucokinase activator with an EC50 of 34 nM.|Product information|CAS Number: 1328987-85-4|Molecular Weight: 586.58|Formula: C27H20F2N2O7S2|Chemical Name: 4-({2-[(2R)-2-[4-(cyclopropanesulfonyl)phenyl]-2-(2,4-difluorophenoxy)acetamido]-1,3-thiazol-5-yl}oxy)benzoic acid|Smiles: OC(=O)C1C=CC(=CC=1)OC1=CN=C(NC(=O)[C@H](OC2=CC=C(F)C=C2F)C2C=CC(=CC=2)S(=O)(=O)C2CC2)S1|InChiKey: XJFUEUNGZVAEIX-XMMPIXPASA-N|InChi: InChI=1S/C27H20F2N2O7S2/c28-17-5-12-22(21(29)13-17)38-24(15-3-8-19(9-4-15)40(35,36)20-10-11-20)25(32)31-27-30-14-23(39-27)37-18-6-1-16(2-7-18)26(33)34/h1-9,12-14,20,24H,10-11H2,(H,33,34)(H,30,31,32)/t24-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Amivantamab} MedChemExpress|{Amivantamab} EGFR|{Amivantamab} Protocol|{Amivantamab} Formula|{Amivantamab} manufacturer|{Amivantamab} Autophagy} |Shelf Life: ≥12 months if stored properly.{{Diphenyl} site|{Diphenyl} Mitochondrial Metabolism|{Diphenyl} Epigenetics|{Diphenyl} Biological Activity|{Diphenyl} In Vivo|{Diphenyl} supplier} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:33200685 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|Glucokinase activator 1 (3 to 300 mg/kg, oral, 180 minutes) shows a dose dependent improvement in glucose excursion in oGTT in a DIO mouse model of T2D. The predominant liver-directed tissue distribution of Glucokinase activator 1 ensures a good safety window with respect to hypoglycemia over a 10-fold dose range.|Products are for research use only. Not for human use.|
