Product Name :
AG1557
Description:
AG1557 is a specific and ATP competitive inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase, has a pIC50 value of 8.194.
CAS:
189290-58-2
Molecular Weight:
407.21
Formula:
C16H14IN3O2
Chemical Name:
N-(3-iodophenyl)-6, 7-dimethoxyquinazolin-4-amine
Smiles :
COC1=CC2=C(NC3=CC(I)=CC=C3)N=CN=C2C=C1OC
InChiKey:
FGCLAQLIXMAIHT-UHFFFAOYSA-N
InChi :
InChI=1S/C16H14IN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
AG1557 is a specific and ATP competitive inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase, has a pIC50 value of 8.{{Sincalide} medchemexpress|{Sincalide} Apoptosis|{Sincalide} Purity & Documentation|{Sincalide} In Vitro|{Sincalide} supplier|{Sincalide} Epigenetic Reader Domain} 194.{{Dexamethasone phosphate disodium} medchemexpress|{Dexamethasone phosphate disodium} Glucocorticoid Receptor|{Dexamethasone phosphate disodium} TGF-beta/Smad|{Dexamethasone phosphate disodium} Technical Information|{Dexamethasone phosphate disodium} Description|{Dexamethasone phosphate disodium} manufacturer} |Product information|CAS Number: 189290-58-2|Molecular Weight: 407.PMID:32828743 21|Formula: C16H14IN3O2|Chemical Name: N-(3-iodophenyl)-6, 7-dimethoxyquinazolin-4-amine|Smiles: COC1=CC2=C(NC3=CC(I)=CC=C3)N=CN=C2C=C1OC|InChiKey: FGCLAQLIXMAIHT-UHFFFAOYSA-N|InChi: InChI=1S/C16H14IN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 83.33 mg/mL (204.64 mM; Need ultrasonic)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Akshada Joshi, et al. Identification of Potential Novel EGFR Inhibitors using a Combination of Pharmacophore and Docking Methods. International Journal of Pharmacy and Pharmaceutical Sciences, ISSN- 0975-1491 Vol 7, Issue 6, 2015Ellis AG, et al. High-performance liquid chromatographic analysis of the tyrphostin AG1478, a specific inhibitor of the epidermal growth factor receptor tyrosine kinase, in mouse plasma. J Chromatogr B Biomed Sci Appl. 2001 Apr 15;754(1):193-9.Products are for research use only. Not for human use.|
