Product Name :
Duocarmycin A
Description:
Duocarmycin A, which is one of well-known antitumor antibiotics, is a DNA alkylator and efficiently alkylates adenine N3 at the 3′ end of AT-rich sequences in the DNA. Duocarmycin A, as a chemotherapeutic agent, results HLC-2 cells typically apoptotic changes, including chromatin condensation, sub-G1 accumulation in DNA histogram pattern, and decrease in procaspase-3 and 9 levels.
CAS:
118292-34-5
Molecular Weight:
507.49
Formula:
C26H25N3O8
Chemical Name:
methyl (1R, 4R, 12S)-4-methyl-3, 7-dioxo-10-(5, 6, 7-trimethoxy-1H-indole-2-carbonyl)-5, 10-diazatetracyclo[7.4.0.0, .0, ]trideca-2(6), 8-diene-4-carboxylate
Smiles :
C[C@]1(NC2=C(C1=O)[C@@]13C[C@@H]1CN(C3=CC2=O)C(=O)C1=CC2=CC(OC)=C(OC)C(OC)=C2N1)C(=O)OC
InChiKey:
AZVARJHZBXHUSO-DZQVEHCYSA-N
InChi :
InChI=1S/C26H25N3O8/c1-25(24(33)37-5)22(31)17-19(28-25)14(30)8-16-26(17)9-12(26)10-29(16)23(32)13-6-11-7-15(34-2)20(35-3)21(36-4)18(11)27-13/h6-8,12,27-28H,9-10H2,1-5H3/t12-,25-,26+/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Duocarmycin A, which is one of well-known antitumor antibiotics, is a DNA alkylator and efficiently alkylates adenine N3 at the 3′ end of AT-rich sequences in the DNA. Duocarmycin A, as a chemotherapeutic agent, results HLC-2 cells typically apoptotic changes, including chromatin condensation, sub-G1 accumulation in DNA histogram pattern, and decrease in procaspase-3 and 9 levels.|Product information|CAS Number: 118292-34-5|Molecular Weight: 507.49|Formula: C26H25N3O8|Chemical Name: methyl (1R, 4R, 12S)-4-methyl-3, 7-dioxo-10-(5, 6, 7-trimethoxy-1H-indole-2-carbonyl)-5, 10-diazatetracyclo[7.4.0.0, .0, ]trideca-2(6), 8-diene-4-carboxylate|Smiles: C[C@]1(NC2=C(C1=O)[C@@]13C[C@@H]1CN(C3=CC2=O)C(=O)C1=CC2=CC(OC)=C(OC)C(OC)=C2N1)C(=O)OC|InChiKey: AZVARJHZBXHUSO-DZQVEHCYSA-N|InChi: InChI=1S/C26H25N3O8/c1-25(24(33)37-5)22(31)17-19(28-25)14(30)8-16-26(17)9-12(26)10-29(16)23(32)13-6-11-7-15(34-2)20(35-3)21(36-4)18(11)27-13/h6-8,12,27-28H,9-10H2,1-5H3/t12-,25-,26+/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Deucravacitinib} web|{Deucravacitinib} Immunology/Inflammation|{Deucravacitinib} Biological Activity|{Deucravacitinib} Data Sheet|{Deucravacitinib} custom synthesis|{Deucravacitinib} Epigenetics} |Shelf Life: ≥12 months if stored properly.{{DOTMA} MedChemExpress|{DOTMA} Metabolic Enzyme/Protease|{DOTMA} Biological Activity|{DOTMA} In Vivo|{DOTMA} supplier|{DOTMA} Cancer} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:31643971 |Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Hirota M, et al. Distamycin A enhances the cytotoxicity of duocarmycin A and suppresses duocarmycin A-induced apoptosis in human lung carcinoma cells. Int J Biochem Cell Biol. 2007;39(5):988-96.Takahashi I, Takahashi K, Ichimura M, Morimoto M, Asano K, Kawamoto I, Tomita F, Nakano H. Duocarmycin A, a new antitumor antibiotic from Streptomyces. J Antibiot (Tokyo). 1988 Dec;41(12):1915-7.Products are for research use only. Not for human use.|
