Product Name :
DC0-NH2
Description:
DC0-NH2 is an effector moiety for ADC and a simplified analog of DC1 with better stability. DC0-NH2 is about 1000-fold more cytotoxic than commonly used anticancer drugs (ex. Doxorubicin). DC0-NH2 can bind to the minor groove of DNA, followed by alkylation of adenine residues by its propabenzindole (CBI) component.
CAS:
615538-51-7
Molecular Weight:
550.01
Formula:
C31H24ClN5O3
Chemical Name:
5-amino-N-{2-[(1S)-1-(chloromethyl)-5-hydroxy-1H, 2H, 3H-benzo[e]indole-3-carbonyl]-1H-indol-5-yl}-1H-indole-2-carboxamide
Smiles :
NC1C=C2C=C(NC2=CC=1)C(=O)NC1C=C2C=C(NC2=CC=1)C(=O)N1C[C@@H](CCl)C2C3=CC=CC=C3C(O)=CC1=2
InChiKey:
PANFWPQOVGEWSD-GOSISDBHSA-N
InChi :
InChI=1S/C31H24ClN5O3/c32-14-18-15-37(27-13-28(38)21-3-1-2-4-22(21)29(18)27)31(40)26-12-17-10-20(6-8-24(17)36-26)34-30(39)25-11-16-9-19(33)5-7-23(16)35-25/h1-13,18,35-36,38H,14-15,33H2,(H,34,39)/t18-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
DC0-NH2 is an effector moiety for ADC and a simplified analog of DC1 with better stability. DC0-NH2 is about 1000-fold more cytotoxic than commonly used anticancer drugs (ex. Doxorubicin). DC0-NH2 can bind to the minor groove of DNA, followed by alkylation of adenine residues by its propabenzindole (CBI) component.{{Umbralisib} site|{Umbralisib} PI3K/Akt/mTOR|{Umbralisib} Protocol|{Umbralisib} In Vitro|{Umbralisib} supplier|{Umbralisib} Epigenetic Reader Domain} |Product information|CAS Number: 615538-51-7|Molecular Weight: 550.{{Anagrelide} medchemexpress|{Anagrelide} Phosphodiesterase (PDE)|{Anagrelide} Protocol|{Anagrelide} Purity|{Anagrelide} custom synthesis|{Anagrelide} Autophagy} 01|Formula: C31H24ClN5O3|Chemical Name: 5-amino-N-{2-[(1S)-1-(chloromethyl)-5-hydroxy-1H, 2H, 3H-benzo[e]indole-3-carbonyl]-1H-indol-5-yl}-1H-indole-2-carboxamide|Smiles: NC1C=C2C=C(NC2=CC=1)C(=O)NC1C=C2C=C(NC2=CC=1)C(=O)N1C[C@@H](CCl)C2C3=CC=CC=C3C(O)=CC1=2|InChiKey: PANFWPQOVGEWSD-GOSISDBHSA-N|InChi: InChI=1S/C31H24ClN5O3/c32-14-18-15-37(27-13-28(38)21-3-1-2-4-22(21)29(18)27)31(40)26-12-17-10-20(6-8-24(17)36-26)34-30(39)25-11-16-9-19(33)5-7-23(16)35-25/h1-13,18,35-36,38H,14-15,33H2,(H,34,39)/t18-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:32886033 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|DC0-NH2 (0-3 nM; 72 hours), in the vitality test of breast cancer cell lines, has a high anti-proliferative effect on Ramos, Namalwa and HL60 / s cells, inhibits the proliferation of Namalwa and HL60 / s cells The IC50 values were 7 pM and 5 pM, respectively, and the inhibition range of COLO205 cells was within 100 pM.|References:|Zhao RY, et al. Synthesis and biological evaluation of antibody conjugates of phosphate prodrugs of cytotoxic DNA alkylators for the targeted treatment of cancer.J Med Chem. 2012 Jan 26;55(2):766-82.Products are for research use only. Not for human use.|
