Product Name :
Anti-ACVR1, Human antibody
Applications:
ELISA,Flow Cyt
Reactivity :
Human
Conjugate:
Unconjugated
Advantages :
High lot-to-lot consistencyIncreased sensitivity and higher affinityAnimal-free production
Description:
| Description: Anti-ACVR1, Human antibody is designed for detecting human ACVR1 specifically. Based on ELISA and/or FCM, Anti-ACVR1, Human antibody reacts with human ACVR1 specifically. | Immunogen: Recombinant human ACVR1 | Host: Alpaca pacous | Isotype: Human IgG1 | Conjugate: Unconjugated | Specificity: Human ACVR1 | Purity: Recombinant Expression and Affinity purified | Concentration: 1mg/ml | Formation: Liquid, 10mM PBS (pH 7.5), 0.05% sucrose, 0.1% trehalose, 0.01% proclin300, 50% Glycerol | Storage: Store at –20 °C, (Avoid freeze / thaw cycles) | Background:Activins are a type of dimeric growth and differentiation factor that belong to the transforming growth factor-beta (TGF-beta) superfamily of signaling proteins. They signal through a complex of receptor serine kinases, which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are transmembrane proteins that have a ligand-binding extracellular domain with a cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, while type II receptors are required for binding ligands and for the expression of type I receptors. Upon ligand binding, type I and II receptors form a stable complex, resulting in the phosphorylation of type I receptors by type II receptors. The ACVR1 gene encodes activin A type I receptor, which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene have been linked to Fibrodysplasia Ossificans Progressiva (FOP), a rare genetic disorder characterized by the formation of bone in muscles, tendons, and other connective tissues, as well as Epicanthus.
Description2 :
Anti-ACVR1, Human antibody is designed for detecting human ACVR1 specifically. Based on ELISA and/or FCM, Anti-ACVR1, Human antibody reacts with human ACVR1 specifically.{{1264-72-8} web|{1264-72-8} Purity & Documentation|{1264-72-8} References|{1264-72-8} manufacturer}
Immunogen:
Recombinant human ACVR1
Host :
Alpaca pacous
Isotype:
Human IgG1
Purity :
Recombinant Expression and Affinity purified
Buffer :
Storage :
Store at –20 °C, (Avoid freeze / thaw cycles)
Function:
ELISA: 1:4,000-1:10000Flow Cytometry：1:200-1:1000Dilution factors are presented in the form of a range because the optimal dilution is a function of many factors, such as antigen density, permeability, etc.{{1438416-21-7} medchemexpress|{1438416-21-7} Protocol|{1438416-21-7} In Vivo|{1438416-21-7} manufacturer} The actual dilution used must be determined empirically.PMID:28552032
