Product Name :
Vofopitant dihydrochloride
Description:
Vofopitant dihydrochloride (GR 205171A) is a potent, selective and orally available tachykinin neurokinin 1(NK1) receptor antagonist, inhibits [3H]SP binding to the NK1 receptor with pKi values of 9.5 and 10.6 in rat and human membranes respectively, acts as a potential broad-spectrum anti-emetic agent.
CAS:
168266-51-1
Molecular Weight:
505.36
Formula:
C21H25Cl2F3N6O
Chemical Name:
(2S,3S)-N-({2-methoxy-5-[5-(trifluoromethyl)-1H-1,2,3,4-tetrazol-1-yl]phenyl}methyl)-2-phenylpiperidin-3-amine dihydrochloride
Smiles :
Cl.Cl.COC1=CC=C(C=C1CN[C@H]1CCCN[C@H]1C1C=CC=CC=1)N1N=NN=C1C(F)(F)F
InChiKey:
YVNRXILPJNISEM-FFUVTKDNSA-N
InChi :
InChI=1S/C21H23F3N6O.2ClH/c1-31-18-10-9-16(30-20(21(22,23)24)27-28-29-30)12-15(18)13-26-17-8-5-11-25-19(17)14-6-3-2-4-7-14;;/h2-4,6-7,9-10,12,17,19,25-26H,5,8,11,13H2,1H3;2*1H/t17-,19-;;/m0../s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Vofopitant dihydrochloride (GR 205171A) is a potent, selective and orally available tachykinin neurokinin 1(NK1) receptor antagonist, inhibits [3H]SP binding to the NK1 receptor with pKi values of 9.5 and 10.6 in rat and human membranes respectively, acts as a potential broad-spectrum anti-emetic agent.|Product information|CAS Number: 168266-51-1|Molecular Weight: 505.36|Formula: C21H25Cl2F3N6O|Chemical Name: (2S,3S)-N-({2-methoxy-5-[5-(trifluoromethyl)-1H-1,2,3,4-tetrazol-1-yl]phenyl}methyl)-2-phenylpiperidin-3-amine dihydrochloride|Smiles: Cl.Cl.COC1=CC=C(C=C1CN[C@H]1CCCN[C@H]1C1C=CC=CC=1)N1N=NN=C1C(F)(F)F|InChiKey: YVNRXILPJNISEM-FFUVTKDNSA-N|InChi: InChI=1S/C21H23F3N6O.2ClH/c1-31-18-10-9-16(30-20(21(22,23)24)27-28-29-30)12-15(18)13-26-17-8-5-11-25-19(17)14-6-3-2-4-7-14;;/h2-4,6-7,9-10,12,17,19,25-26H,5,8,11,13H2,1H3;2*1H/t17-,19-;;/m0.{{Squalene} web|{Squalene} Reactive Oxygen Species|{Squalene} Protocol|{Squalene} References|{Squalene} manufacturer|{Squalene} Cancer} .{{Hyaluronic acid} web|{Hyaluronic acid} Anti-infection|{Hyaluronic acid} Biological Activity|{Hyaluronic acid} Purity|{Hyaluronic acid} manufacturer|{Hyaluronic acid} Autophagy} /s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 33.PMID:32098531 33 mg/mL (65.95 mM; Need ultrasonic). H2O : 33.33 mg/mL (65.95 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
