Product Name :
HUHS015
Description:
HUHS015 is a potent prostate cancer antigen-1 (PCA-1/ALKBH3) inhibitor with an IC50 of 0.67μM for PCA-1.
CAS:
1453097-13-6
Molecular Weight:
318.37
Formula:
C19H18N4O
Chemical Name:
4-benzyl-5-methyl-2-(6-methyl-1H-1,3-benzodiazol-2-yl)-2,3-dihydro-1H-pyrazol-3-one
Smiles :
CC1C=C2NC(=NC2=CC=1)N1NC(C)=C(CC2C=CC=CC=2)C1=O
InChiKey:
IQOKQFQFGHZHJT-UHFFFAOYSA-N
InChi :
InChI=1S/C19H18N4O/c1-12-8-9-16-17(10-12)21-19(20-16)23-18(24)15(13(2)22-23)11-14-6-4-3-5-7-14/h3-10,22H,11H2,1-2H3,(H,20,21)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
HUHS015 is a potent prostate cancer antigen-1 (PCA-1/ALKBH3) inhibitor with an IC50 of 0.67μM for PCA-1.|Product information|CAS Number: 1453097-13-6|Molecular Weight: 318.37|Formula: C19H18N4O|Chemical Name: 4-benzyl-5-methyl-2-(6-methyl-1H-1,3-benzodiazol-2-yl)-2,3-dihydro-1H-pyrazol-3-one|Smiles: CC1C=C2NC(=NC2=CC=1)N1NC(C)=C(CC2C=CC=CC=2)C1=O|InChiKey: IQOKQFQFGHZHJT-UHFFFAOYSA-N|InChi: InChI=1S/C19H18N4O/c1-12-8-9-16-17(10-12)21-19(20-16)23-18(24)15(13(2)22-23)11-14-6-4-3-5-7-14/h3-10,22H,11H2,1-2H3,(H,20,21)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 34 mg/mL (106.{{L-Phenylalanine} site|{L-Phenylalanine} Membrane Transporter/Ion Channel|{L-Phenylalanine} Purity & Documentation|{L-Phenylalanine} In Vivo|{L-Phenylalanine} supplier|{L-Phenylalanine} Autophagy} 79 mM).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Paclitaxel} web|{Paclitaxel} Antibody-drug Conjugate/ADC Related|{Paclitaxel} Biological Activity|{Paclitaxel} Formula|{Paclitaxel} manufacturer|{Paclitaxel} Autophagy} |Shelf Life: ≥12 months if stored properly.PMID:32553551 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|HUHS015 significantly suppresses the growth of DU145 cells, which are human hormone-independent prostate cancer cells.|In Vivo:|HUHS015 potently suppresses the growth of DU145 cells in a mouse xenograft model. HUHS015 displays 7.2% bioavailability (BA) in rats after oral administration.|Products are for research use only. Not for human use.|
