Product Name :
(S, R, S)-AHPC-Me-C10-NH2
Description:
(S, R, S)-AHPC-Me-C10-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the a VHL ligand and a linker. (S, R, S)-AHPC-Me-C10-NH2 can be used in PROTAC MS432 (HY-130602).
CAS:
2376139-52-3
Molecular Weight:
627.88
Formula:
C34H53N5O4S
Chemical Name:
(2S, 4R)-1-[(2S)-2-(11-aminoundecanamido)-3, 3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1, 3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide
Smiles :
CC1N=CSC=1C1C=CC(=CC=1)[C@H](C)NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](NC(=O)CCCCCCCCCCN)C(C)(C)C
InChiKey:
AJVUUWWUFQQMNH-GOGGMHKJSA-N
InChi :
InChI=1S/C34H53N5O4S/c1-23(25-15-17-26(18-16-25)30-24(2)36-22-44-30)37-32(42)28-20-27(40)21-39(28)33(43)31(34(3,4)5)38-29(41)14-12-10-8-6-7-9-11-13-19-35/h15-18,22-23,27-28,31,40H,6-14,19-21,35H2,1-5H3,(H,37,42)(H,38,41)/t23-,27+,28-,31+/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{AARS1 Protein, Mouse (sf9, His, solution)} medchemexpress|{AARS1 Protein, Mouse (sf9, His, solution)} Protocol|{AARS1 Protein, Mouse (sf9, His, solution)} References|{AARS1 Protein, Mouse (sf9, His, solution)} manufacturer|{AARS1 Protein, Mouse (sf9, His, solution)} Autophagy}
Shelf Life:
≥12 months if stored properly.{{Brentuximab} MedChemExpress|{Brentuximab} Antibody-drug Conjugate/ADC Related|{Brentuximab} Protocol|{Brentuximab} In stock|{Brentuximab} manufacturer|{Brentuximab} Epigenetic Reader Domain}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
(S, R, S)-AHPC-Me-C10-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the a VHL ligand and a linker. (S, R, S)-AHPC-Me-C10-NH2 can be used in PROTAC MS432 (HY-130602).PMID:33085434 |Product information|CAS Number: 2376139-52-3|Molecular Weight: 627.88|Formula: C34H53N5O4S|Chemical Name: (2S, 4R)-1-[(2S)-2-(11-aminoundecanamido)-3, 3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1, 3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide|Smiles: CC1N=CSC=1C1C=CC(=CC=1)[C@H](C)NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](NC(=O)CCCCCCCCCCN)C(C)(C)C|InChiKey: AJVUUWWUFQQMNH-GOGGMHKJSA-N|InChi: InChI=1S/C34H53N5O4S/c1-23(25-15-17-26(18-16-25)30-24(2)36-22-44-30)37-32(42)28-20-27(40)21-39(28)33(43)31(34(3,4)5)38-29(41)14-12-10-8-6-7-9-11-13-19-35/h15-18,22-23,27-28,31,40H,6-14,19-21,35H2,1-5H3,(H,37,42)(H,38,41)/t23-,27+,28-,31+/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|MS432 is a first-in-class and highly selective PD0325901-based VHL-recruiting PROTAC degrader for MEK1 and MEK2.|References:|Wei J, et al. Discovery of a First-in-Class Mitogen-Activated Protein Kinase Kinase 1/2 Degrader. J Med Chem. 2019 Dec 12;62(23):10897-10911.Products are for research use only. Not for human use.|
