Product Name :
TC-SP 14
Description:
EC50: 0.042 μM for hS1P1 TC-SP 14 is an agonist of Sphingosine-1-Phosphate Receptor 1 (S1P1). Studies have revealed that the lysophospholipid sphingosine-1-phosphate (S1P1) is a pleiotropic modulator of diverse cellular processes. Such effects are reported to be mediated by the interactions of S1P with a set of paralogous G proteincoupled receptors, which are widely expressed in the immune, central nervous and cardiovascular systems. In vitro: As a small lipophilic substituent proved equally effective to a larger substituent in reducing S1P3 activity, TC-SP 14 was screened. TC-SP 14 was found to be a potent S1P1 agonist (EC50 = 0.042 μM) with reduced activity for S1P3 (EC50 = 3.47 μM) . In vivo: In Lewis rats, TC-SP 14 produced a dose-dependent reduction in circulating blood lymphocytes, which was consistent with S1P1 agonism. Moreover, statistical significance was shown at a dose of 0.3 mg/kg, and the dose fo 3.0 mg/kg led to near maximal lymphopenia. TC-SP 14 was subsequently investigated in a DTH antigen challenge model. Results showed a statistically significant reduction in ear swelling at doses of 0.3 mg/kg and higher. In addition, reduced ear swelling was found to closely track circulating lymphocyte counts . Clinical trial: N/A
CAS:
1257093-40-5
Molecular Weight:
450.50
Formula:
C25H20F2N2O2S
Chemical Name:
1-[(3-fluoro-4-{5-[(2-fluorophenyl)methyl]-1,3-benzothiazol-2-yl}phenyl)methyl]azetidine-3-carboxylic acid
Smiles :
OC(=O)C1CN(CC2=CC(F)=C(C=C2)C2=NC3=CC(CC4=CC=CC=C4F)=CC=C3S2)C1
InChiKey:
GVXGVDIXINMAAL-UHFFFAOYSA-N
InChi :
InChI=1S/C25H20F2N2O2S/c26-20-4-2-1-3-17(20)9-15-6-8-23-22(11-15)28-24(32-23)19-7-5-16(10-21(19)27)12-29-13-18(14-29)25(30)31/h1-8,10-11,18H,9,12-14H2,(H,30,31)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Surfactin} medchemexpress|{Surfactin} HSV|{Surfactin} Biological Activity|{Surfactin} Formula|{Surfactin} supplier|{Surfactin} Epigenetics}
Shelf Life:
≥12 months if stored properly.{{Niraparib} site|{Niraparib} PARP|{Niraparib} Purity & Documentation|{Niraparib} Description|{Niraparib} manufacturer|{Niraparib} Cancer}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:25147652
Additional information:
EC50: 0.042 μM for hS1P1 TC-SP 14 is an agonist of Sphingosine-1-Phosphate Receptor 1 (S1P1). Studies have revealed that the lysophospholipid sphingosine-1-phosphate (S1P1) is a pleiotropic modulator of diverse cellular processes. Such effects are reported to be mediated by the interactions of S1P with a set of paralogous G proteincoupled receptors, which are widely expressed in the immune, central nervous and cardiovascular systems. In vitro: As a small lipophilic substituent proved equally effective to a larger substituent in reducing S1P3 activity, TC-SP 14 was screened. TC-SP 14 was found to be a potent S1P1 agonist (EC50 = 0.042 μM) with reduced activity for S1P3 (EC50 = 3.47 μM) . In vivo: In Lewis rats, TC-SP 14 produced a dose-dependent reduction in circulating blood lymphocytes, which was consistent with S1P1 agonism. Moreover, statistical significance was shown at a dose of 0.3 mg/kg, and the dose fo 3.0 mg/kg led to near maximal lymphopenia. TC-SP 14 was subsequently investigated in a DTH antigen challenge model. Results showed a statistically significant reduction in ear swelling at doses of 0.3 mg/kg and higher. In addition, reduced ear swelling was found to closely track circulating lymphocyte counts . Clinical trial: N/A|Product information|CAS Number: 1257093-40-5|Molecular Weight: 450.50|Formula: C25H20F2N2O2S|Chemical Name: 1-[(3-fluoro-4-{5-[(2-fluorophenyl)methyl]-1,3-benzothiazol-2-yl}phenyl)methyl]azetidine-3-carboxylic acid|Smiles: OC(=O)C1CN(CC2=CC(F)=C(C=C2)C2=NC3=CC(CC4=CC=CC=C4F)=CC=C3S2)C1|InChiKey: GVXGVDIXINMAAL-UHFFFAOYSA-N|InChi: InChI=1S/C25H20F2N2O2S/c26-20-4-2-1-3-17(20)9-15-6-8-23-22(11-15)28-24(32-23)19-7-5-16(10-21(19)27)12-29-13-18(14-29)25(30)31/h1-8,10-11,18H,9,12-14H2,(H,30,31)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
