Product Name :
MIR96-IN-1
Description:
MIR96-IN-1 targets the Drosha site in the miR-96 (miRNA-96, microRNA-96) hairpin precursor, inhibiting its biogenesis, derepressing downstream targets, and triggering apoptosis in breast cancer cells. MIR96-IN-1 binds to RNAs with Kds of 1.3, 9.4, 3.4, 1.3 and 7.4 μM for RNA1, RNA2, RNA3, RNA4 and RNA5, respectively.
CAS:
1311982-88-3
Molecular Weight:
588.79
Formula:
C33H48N8O2
Chemical Name:
N-(3-azidopropyl)-4-{2,6-di-tert-butyl-4-[6-(4-methylpiperazin-1-yl)-1H-1,3-benzodiazol-2-yl]phenoxy}butanamide
Smiles :
CN1CCN(CC1)C1C=C2NC(=NC2=CC=1)C1=CC(=C(OCCCC(=O)NCCCN=[N+]=[N-])C(=C1)C(C)(C)C)C(C)(C)C
InChiKey:
LTPQCIXFOJELHJ-UHFFFAOYSA-N
InChi :
InChI=1S/C33H48N8O2/c1-32(2,3)25-20-23(31-37-27-12-11-24(22-28(27)38-31)41-17-15-40(7)16-18-41)21-26(33(4,5)6)30(25)43-19-8-10-29(42)35-13-9-14-36-39-34/h11-12,20-22H,8-10,13-19H2,1-7H3,(H,35,42)(H,37,38)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Eliapixant} web|{Eliapixant} P2X Receptor|{Eliapixant} Biological Activity|{Eliapixant} In Vitro|{Eliapixant} manufacturer|{Eliapixant} Autophagy}
Additional information:
MIR96-IN-1 targets the Drosha site in the miR-96 (miRNA-96, microRNA-96) hairpin precursor, inhibiting its biogenesis, derepressing downstream targets, and triggering apoptosis in breast cancer cells. MIR96-IN-1 binds to RNAs with Kds of 1.3, 9.4, 3.4, 1.3 and 7.4 μM for RNA1, RNA2, RNA3, RNA4 and RNA5, respectively.{{Pentagastrin} web|{Pentagastrin} Neuronal Signaling|{Pentagastrin} Epigenetics|{Pentagastrin} Technical Information|{Pentagastrin} References|{Pentagastrin} manufacturer} |Product information|CAS Number: 1311982-88-3|Molecular Weight: 588.PMID:27102143 79|Formula: C33H48N8O2|Chemical Name: N-(3-azidopropyl)-4-{2,6-di-tert-butyl-4-[6-(4-methylpiperazin-1-yl)-1H-1,3-benzodiazol-2-yl]phenoxy}butanamide|Smiles: CN1CCN(CC1)C1C=C2NC(=NC2=CC=1)C1=CC(=C(OCCCC(=O)NCCCN=[N+]=[N-])C(=C1)C(C)(C)C)C(C)(C)C|InChiKey: LTPQCIXFOJELHJ-UHFFFAOYSA-N|InChi: InChI=1S/C33H48N8O2/c1-32(2,3)25-20-23(31-37-27-12-11-24(22-28(27)38-31)41-17-15-40(7)16-18-41)21-26(33(4,5)6)30(25)43-19-8-10-29(42)35-13-9-14-36-39-34/h11-12,20-22H,8-10,13-19H2,1-7H3,(H,35,42)(H,37,38)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 100 mg/mL (169.84 mM).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|MIR96-IN-1 (Compound 1) selectively inhibits production of mature miR-96 and triggers apoptosis in breast cancer cells at micromolar concentrations. MIR96-IN-1 (Compound 3) binds a UU loop in miR-96 and inhibits its biogenesis.|Products are for research use only. Not for human use.|
