Product Name :
NV-5138 hydrochloride
Description:
NV-5138 hydrochloride, a leucine analog, is the first selective and orally active brain mTORC1 activator, binding to Sestrin2. NV-5138 hydrochloride is used for antidepressant studies.
CAS:
2639392-70-2
Molecular Weight:
217.64
Formula:
C7H14ClF2NO2
Chemical Name:
(2S)-2-amino-5,5-difluoro-4,4-dimethylpentanoic acid hydrochloride
Smiles :
Cl.CC(C)(C[C@H](N)C(O)=O)C(F)F
InChiKey:
SIUFCONWYBJSOP-WCCKRBBISA-N
InChi :
InChI=1S/C7H13F2NO2.ClH/c1-7(2,6(8)9)3-4(10)5(11)12;/h4,6H,3,10H2,1-2H3,(H,11,12);1H/t4-;/m0./s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
NV-5138 hydrochloride, a leucine analog, is the first selective and orally active brain mTORC1 activator, binding to Sestrin2. NV-5138 hydrochloride is used for antidepressant studies.|Product information|CAS Number: 2639392-70-2|Molecular Weight: 217.64|Formula: C7H14ClF2NO2|Chemical Name: (2S)-2-amino-5,5-difluoro-4,4-dimethylpentanoic acid hydrochloride|Smiles: Cl.CC(C)(C[C@H](N)C(O)=O)C(F)F|InChiKey: SIUFCONWYBJSOP-WCCKRBBISA-N|InChi: InChI=1S/C7H13F2NO2.ClH/c1-7(2,6(8)9)3-4(10)5(11)12;/h4,6H,3,10H2,1-2H3,(H,11,12);1H/t4-;/m0./s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 250 mg/mL (1148.69 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Flunarizine} site|{Flunarizine} Sodium Channel|{Flunarizine} Technical Information|{Flunarizine} In stock|{Flunarizine} manufacturer|{Flunarizine} Autophagy} |Shelf Life: ≥12 months if stored properly.{{Fruquintinib} web|{Fruquintinib} VEGFR|{Fruquintinib} Purity & Documentation|{Fruquintinib} Description|{Fruquintinib} custom synthesis|{Fruquintinib} Epigenetic Reader Domain} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:27102143 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|NV-5138 is found to be essentially 100% orally bioavailable with an elimination half-life in plasma of ~ 3 h determined following intravenous and oral dosing in rats. NV-5138 (160 mg/kg, po, single dose) rapidly increases levels of phospho-mTOR as well as the downstream targets, phospho-p70S6K1, and phosphor-4EB-P1, in synaptosomal preparations of PFC. NV-5138 (80 mg/kg, po, daily for a total of 7 days) also produces antidepressant effects.|Products are for research use only. Not for human use.|
