Product Name :
GW-870086
Description:
GW-870086 is a glucocorticoid receptor agonist potentially for the treatment of asthma and atopic dermatitis.
CAS:
827319-43-7
Molecular Weight:
559.64
Formula:
C31H39F2NO6
Chemical Name:
Androsta-1,4-diene-17-carboxylic acid, 6,9-difluoro-11-hydroxy-16-methyl-3-oxo-17-(((2,2,3,3-tetramethylcyclopropyl)carbonyl)oxy)-, cyanomethyl ester, (6alpha,11beta,16alpha,17alpha)-
Smiles :
C[C@@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@]1(OC(=O)C1C(C)(C)C1(C)C)C(=O)OCC#N
InChiKey:
WUBKGTSFJSEIEM-RGAPXVORSA-N
InChi :
InChI=1S/C31H39F2NO6/c1-16-12-18-19-14-21(32)20-13-17(35)8-9-28(20,6)30(19,33)22(36)15-29(18,7)31(16,25(38)39-11-10-34)40-24(37)23-26(2,3)27(23,4)5/h8-9,13,16,18-19,21-23,36H,11-12,14-15H2,1-7H3/t16-,18+,19+,21+,22+,28+,29+,30+,31-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
GW-870086 is a glucocorticoid receptor agonist potentially for the treatment of asthma and atopic dermatitis.|Product information|CAS Number: 827319-43-7|Molecular Weight: 559.64|Formula: C31H39F2NO6|Synonym:|GW870086X|Chemical Name: Androsta-1,4-diene-17-carboxylic acid, 6,9-difluoro-11-hydroxy-16-methyl-3-oxo-17-(((2,2,3,3-tetramethylcyclopropyl)carbonyl)oxy)-, cyanomethyl ester, (6alpha,11beta,16alpha,17alpha)-|Smiles: C[C@@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@]1(OC(=O)C1C(C)(C)C1(C)C)C(=O)OCC#N|InChiKey: WUBKGTSFJSEIEM-RGAPXVORSA-N|InChi: InChI=1S/C31H39F2NO6/c1-16-12-18-19-14-21(32)20-13-17(35)8-9-28(20,6)30(19,33)22(36)15-29(18,7)31(16,25(38)39-11-10-34)40-24(37)23-26(2,3)27(23,4)5/h8-9,13,16,18-19,21-23,36H,11-12,14-15H2,1-7H3/t16-,18+,19+,21+,22+,28+,29+,30+,31-/m1/s1|Technical Data|Appearance: Solid Power.|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Flucytosine} web|{Flucytosine} Anti-infection|{Flucytosine} Biological Activity|{Flucytosine} In Vitro|{Flucytosine} supplier|{Flucytosine} Cancer} |Shelf Life: ≥360 days if stored properly.{{Anti-HA Affinity Gel} medchemexpress|{Anti-HA Affinity Gel} TGF-beta/Smad|{Anti-HA Affinity Gel} Purity & Documentation|{Anti-HA Affinity Gel} References|{Anti-HA Affinity Gel} manufacturer} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:36014399 |Drug Formulation: To be determined.|HS Tariff Code: 382200|References:|Uings IJ, Needham D, Matthews J, Haase M, Austin R, Angell D, Leavens K, Holt J, Biggadike K, Farrow SN. Discovery of GW870086: a potent anti-inflammatory steroid with a unique pharmacological profile. Br J Pharmacol. 2013 Jul;169(6):1389-403. doi: 10.1111/bph.12232. PubMed PMID: 23639214; PubMed Central PMCID: PMC3831715.Bareille P, Hardes K, Donald AC. Efficacy and safety of once-daily GW870086 a novel selective glucocorticoid in mild-moderate asthmatics: a randomised, two-way crossover, controlled clinical trial. J Asthma. 2013 Dec;50(10):1077-82. doi: 10.3109/02770903.2013.837480. PubMed PMID: 23991670.Products are for research use only. Not for human use.|
