Product Name :
GSK-LSD1 — LSD1 Inhibitor
Description:
GSK-LSD1 is a highly potent, specific and irreversible inhibitor of Lysine Specific Demethylase-1 (LSD1). It inhibits LSD1 in biochemical assay with an IC50 ~16 nM, and is > 1000 fold selective over other closely related FAD utilizing enzymes (i.e. LSD2, MAO-A, MAO-B). GSK-LSD1 induces gene expression changes in cancer cell lines (average EC50 < 5 nM) and inhibits cancer cell line growth (average EC50 < 5 nM).
CAS:
2102933-95-7
Molecular Weight:
289.24
Formula:
C14H22Cl2N2
Chemical Name:
N-((1R,2S)-2-phenylcyclopropyl)piperidin-4-amine HCl salt
Smiles :
Cl.Cl.C1[C@H]([C@@H]1NC1CCNCC1)C1C=CC=CC=1
InChiKey:
PJFZOGMSPBHPNS-WICJZZOFSA-N
InChi :
InChI=1S/C14H20N2.{{Esomeprazole} medchemexpress|{Esomeprazole} Proton Pump|{Esomeprazole} Purity & Documentation|{Esomeprazole} In Vivo|{Esomeprazole} supplier|{Esomeprazole} Cancer} 2ClH/c1-2-4-11(5-3-1)13-10-14(13)16-12-6-8-15-9-7-12;;/h1-5,12-16H,6-10H2;2*1H/t13-,14+;;/m0../s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
GSK-LSD1 is a highly potent, specific and irreversible inhibitor of Lysine Specific Demethylase-1 (LSD1). It inhibits LSD1 in biochemical assay with an IC50 ~16 nM, and is > 1000 fold selective over other closely related FAD utilizing enzymes (i.e. LSD2, MAO-A, MAO-B). GSK-LSD1 induces gene expression changes in cancer cell lines (average EC50 Product information|CAS Number: 2102933-95-7|Molecular Weight: 289.24|Formula: C14H22Cl2N2|Chemical Name: N-((1R,2S)-2-phenylcyclopropyl)piperidin-4-amine HCl salt|Smiles: Cl.{{Tivantinib} medchemexpress|{Tivantinib} Protein Tyrosine Kinase/RTK|{Tivantinib} NF-κB|{Tivantinib} Protocol|{Tivantinib} In stock|{Tivantinib} custom synthesis} Cl.PMID:23554582 C1[C@H]([C@@H]1NC1CCNCC1)C1C=CC=CC=1|InChiKey: PJFZOGMSPBHPNS-WICJZZOFSA-N|InChi: InChI=1S/C14H20N2.2ClH/c1-2-4-11(5-3-1)13-10-14(13)16-12-6-8-15-9-7-12;;/h1-5,12-16H,6-10H2;2*1H/t13-,14+;;/m0../s1|Technical Data|Appearance: Solid Power.|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO up to 100 mM|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined.|HS Tariff Code: 382200|How to use|In Vitro:|GSK-LSD1 was used at 1 µM in vitro.|References:|http://www.thesgc.org/chemical-probes/epigeneticsProducts are for research use only. Not for human use.|Documents||
