Product Name :
Propyl pyrazole triol
Description:
Propyl pyrazole triol (PPT) is a selective estrogen receptor alpha (ERα) agonist. The relative binding affinity of Propyl pyrazole triol for ERα (ERα: 49%) around 410 times higher compared with estrogen receptor beta (ERβ: 0.12%).
CAS:
263717-53-9
Molecular Weight:
386.44
Formula:
C24H22N2O3
Chemical Name:
4-[1,3-bis(4-hydroxyphenyl)-4-propyl-1H-pyrazol-5-yl]phenol
Smiles :
CCCC1C(=NN(C=1C1C=CC(O)=CC=1)C1C=CC(O)=CC=1)C1C=CC(O)=CC=1
InChiKey:
IOTXSIGGFRQYKW-UHFFFAOYSA-N
InChi :
InChI=1S/C24H22N2O3/c1-2-3-22-23(16-4-10-19(27)11-5-16)25-26(18-8-14-21(29)15-9-18)24(22)17-6-12-20(28)13-7-17/h4-15,27-29H,2-3H2,1H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Propyl pyrazole triol (PPT) is a selective estrogen receptor alpha (ERα) agonist. The relative binding affinity of Propyl pyrazole triol for ERα (ERα: 49%) around 410 times higher compared with estrogen receptor beta (ERβ: 0.12%).|Product information|CAS Number: 263717-53-9|Molecular Weight: 386.44|Formula: C24H22N2O3|Chemical Name: 4-[1,3-bis(4-hydroxyphenyl)-4-propyl-1H-pyrazol-5-yl]phenol|Smiles: CCCC1C(=NN(C=1C1C=CC(O)=CC=1)C1C=CC(O)=CC=1)C1C=CC(O)=CC=1|InChiKey: IOTXSIGGFRQYKW-UHFFFAOYSA-N|InChi: InChI=1S/C24H22N2O3/c1-2-3-22-23(16-4-10-19(27)11-5-16)25-26(18-8-14-21(29)15-9-18)24(22)17-6-12-20(28)13-7-17/h4-15,27-29H,2-3H2,1H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 100 mg/mL (258.77 mM).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Doxorubicin} site|{Doxorubicin} Autophagy|{Doxorubicin} Biological Activity|{Doxorubicin} Description|{Doxorubicin} custom synthesis|{Doxorubicin} Epigenetics} |Shelf Life: ≥12 months if stored properly.{{Pravastatin} medchemexpress|{Pravastatin} Autophagy|{Pravastatin} Purity & Documentation|{Pravastatin} References|{Pravastatin} manufacturer|{Pravastatin} Epigenetics} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23618405 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|The EC50 of Propyl pyrazole triol for the ERα-dependent response is 140 pM in ERα-U2OS-Luc cells.|References:|Influence of cellular ERalpha/ERbeta ratio on the ERalpha-agonist induced proliferation of human T47D breast cancer cells.Stauffer SR, et al. Pyrazole ligands: structure-affinity/activity relationships and estrogen receptor-alpha-selective agonists. J Med Chem. 2000 Dec 28;43(26):4934-47.Products are for research use only. Not for human use.|
