Product Name :
PF-03814735
Description:
PF-03814735 is an orally bioavailable, ATP-competitive, reversible small-molecule Aurora kinase inhibitor with potential antineoplastic activity. Aurora kinase inhibitor PF-03814735 binds to and inhibits Aurora kinases A and B, which may result in the inhibition of cellular division and proliferation in tumor cells that overexpress these kinases. Aurora kinases are serine-threonine kinases that play essential roles in mitotic checkpoint control during mitosis.
CAS:
942487-16-3
Molecular Weight:
474.48
Formula:
C23H25F3N6O2
Chemical Name:
N-{2-[(1R,8S)-4-{[4-(cyclobutylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}-11-azatricyclo[6.2.1.0²,⁷]undeca-2(7),3,5-trien-11-yl]-2-oxoethyl}acetamide
Smiles :
CC(=O)NCC(=O)N1[C@@H]2CC[C@H]1C1=CC=C(C=C12)NC1=NC(NC2CCC2)=C(C=N1)C(F)(F)F
InChiKey:
RYYNGWLOYLRZLK-RBUKOAKNSA-N
InChi :
InChI=1S/C23H25F3N6O2/c1-12(33)27-11-20(34)32-18-7-8-19(32)16-9-14(5-6-15(16)18)30-22-28-10-17(23(24,25)26)21(31-22)29-13-3-2-4-13/h5-6,9-10,13,18-19H,2-4,7-8,11H2,1H3,(H,27,33)(H2,28,29,30,31)/t18-,19+/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Anetumab} medchemexpress|{Anetumab} Mesothelin|{Anetumab} Technical Information|{Anetumab} Description|{Anetumab} manufacturer|{Anetumab} Autophagy}
Additional information:
PF-03814735 is an orally bioavailable, ATP-competitive, reversible small-molecule Aurora kinase inhibitor with potential antineoplastic activity.{{Buspirone} web|{Buspirone} Dopamine Receptor|{Buspirone} Purity & Documentation|{Buspirone} In stock|{Buspirone} custom synthesis|{Buspirone} Autophagy} Aurora kinase inhibitor PF-03814735 binds to and inhibits Aurora kinases A and B, which may result in the inhibition of cellular division and proliferation in tumor cells that overexpress these kinases. Aurora kinases are serine-threonine kinases that play essential roles in mitotic checkpoint control during mitosis.|Product information|CAS Number: 942487-16-3|Molecular Weight: 474.48|Formula: C23H25F3N6O2|Chemical Name: N-{2-[(1R,8S)-4-{[4-(cyclobutylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}-11-azatricyclo[6.2.1.0²,⁷]undeca-2(7),3,5-trien-11-yl]-2-oxoethyl}acetamide|Smiles: CC(=O)NCC(=O)N1[C@@H]2CC[C@H]1C1=CC=C(C=C12)NC1=NC(NC2CCC2)=C(C=N1)C(F)(F)F|InChiKey: RYYNGWLOYLRZLK-RBUKOAKNSA-N|InChi: InChI=1S/C23H25F3N6O2/c1-12(33)27-11-20(34)32-18-7-8-19(32)16-9-14(5-6-15(16)18)30-22-28-10-17(23(24,25)26)21(31-22)29-13-3-2-4-13/h5-6,9-10,13,18-19H,2-4,7-8,11H2,1H3,(H,27,33)(H2,28,29,30,31)/t18-,19+/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:23600560 |Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
