Product Name :
Perospirone
Description:
Perospirone (SM-9018 free base) is an orally active antagonist of 5-HT2A receptor (Ki=0.6 nM) and dopamine D2 receptor (Ki=1.4 nM), and also a partial agonist of 5-HT1A receptor (Ki=2.9 nM). Perospirone is an atypical antipsychotic agent and has the potential for schizophrenic disease research.
CAS:
150915-41-6
Molecular Weight:
426.57
Formula:
C23H30N4O2S
Chemical Name:
(3aR,7aS)-2-{4-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]butyl}-octahydro-1H-isoindole-1,3-dione
Smiles :
O=C1[C@H]2CCCC[C@H]2C(=O)N1CCCCN1CCN(CC1)C1=NSC2=CC=CC=C21
InChiKey:
FBVFZWUMDDXLLG-HDICACEKSA-N
InChi :
InChI=1S/C23H30N4O2S/c28-22-17-7-1-2-8-18(17)23(29)27(22)12-6-5-11-25-13-15-26(16-14-25)21-19-9-3-4-10-20(19)30-24-21/h3-4,9-10,17-18H,1-2,5-8,11-16H2/t17-,18+
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Perospirone (SM-9018 free base) is an orally active antagonist of 5-HT2A receptor (Ki=0.6 nM) and dopamine D2 receptor (Ki=1.4 nM), and also a partial agonist of 5-HT1A receptor (Ki=2.{{Resmetirom} MedChemExpress|{Resmetirom} Thyroid Hormone Receptor|{Resmetirom} Biological Activity|{Resmetirom} References|{Resmetirom} supplier|{Resmetirom} Autophagy} 9 nM).{{Bapineuzumab} web|{Bapineuzumab} Neuronal Signaling|{Bapineuzumab} Biological Activity|{Bapineuzumab} Formula|{Bapineuzumab} manufacturer|{Bapineuzumab} Epigenetics} Perospirone is an atypical antipsychotic agent and has the potential for schizophrenic disease research.PMID:24059181 |Product information|CAS Number: 150915-41-6|Molecular Weight: 426.57|Formula: C23H30N4O2S|Chemical Name: (3aR,7aS)-2-{4-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]butyl}-octahydro-1H-isoindole-1,3-dione|Smiles: O=C1[C@H]2CCCC[C@H]2C(=O)N1CCCCN1CCN(CC1)C1=NSC2=CC=CC=C21|InChiKey: FBVFZWUMDDXLLG-HDICACEKSA-N|InChi: InChI=1S/C23H30N4O2S/c28-22-17-7-1-2-8-18(17)23(29)27(22)12-6-5-11-25-13-15-26(16-14-25)21-19-9-3-4-10-20(19)30-24-21/h3-4,9-10,17-18H,1-2,5-8,11-16H2/t17-,18+|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 5 mg/mL (11.72 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Perospirone (SM-9018 free base) possesses moderate affinities for α1, 5-HT1, and D1 receptors (Ki=17, 18 and 41 nM, respectively) .|In Vivo:|Perospirone (SM-9018 free base; 1.0-10.0 mg/kg/day; orally; for 14 consecutive days) significantly attenuates PCP-induced cognitive deficits in mice in a dose-dependent manner.|Products are for research use only. Not for human use.|
