Product Name :
AZD-9833
Description:
AZD-9833 is a potent and orally active estrogen receptor (ER) antagonist. AZD-9833 is used for the study of ER+ HER2-advanced breast cancer.
CAS:
2222844-89-3
Molecular Weight:
476.51
Formula:
C24H28F4N6
Chemical Name:
N-[1-(3-fluoropropyl)azetidin-3-yl]-6-[(6S,8R)-8-methyl-7-(2,2,2-trifluoroethyl)-3H,6H,7H,8H,9H-pyrido[4,3-e]indazol-6-yl]pyridin-3-amine
Smiles :
C[C@@H]1CC2C(=CC=C3NN=CC=23)[C@@H](C2=CC=C(C=N2)NC2CN(CCCF)C2)N1CC(F)(F)F
InChiKey:
WDHOIABIERMLGY-CMJOXMDJSA-N
InChi :
InChI=1S/C24H28F4N6/c1-15-9-19-18(4-6-21-20(19)11-30-32-21)23(34(15)14-24(26,27)28)22-5-3-16(10-29-22)31-17-12-33(13-17)8-2-7-25/h3-6,10-11,15,17,23,31H,2,7-9,12-14H2,1H3,(H,30,32)/t15-,23+/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Aducanumab} web|{Aducanumab} Neuronal Signaling|{Aducanumab} Purity & Documentation|{Aducanumab} In stock|{Aducanumab} supplier|{Aducanumab} Autophagy}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
AZD-9833 is a potent and orally active estrogen receptor (ER) antagonist. AZD-9833 is used for the study of ER+ HER2-advanced breast cancer.|Product information|CAS Number: 2222844-89-3|Molecular Weight: 476.{{LCS-1} web|{LCS-1} SOD|{LCS-1} Purity & Documentation|{LCS-1} Purity|{LCS-1} supplier|{LCS-1} Epigenetic Reader Domain} 51|Formula: C24H28F4N6|Chemical Name: N-[1-(3-fluoropropyl)azetidin-3-yl]-6-[(6S,8R)-8-methyl-7-(2,2,2-trifluoroethyl)-3H,6H,7H,8H,9H-pyrido[4,3-e]indazol-6-yl]pyridin-3-amine|Smiles: C[C@@H]1CC2C(=CC=C3NN=CC=23)[C@@H](C2=CC=C(C=N2)NC2CN(CCCF)C2)N1CC(F)(F)F|InChiKey: WDHOIABIERMLGY-CMJOXMDJSA-N|InChi: InChI=1S/C24H28F4N6/c1-15-9-19-18(4-6-21-20(19)11-30-32-21)23(34(15)14-24(26,27)28)22-5-3-16(10-29-22)31-17-12-33(13-17)8-2-7-25/h3-6,10-11,15,17,23,31H,2,7-9,12-14H2,1H3,(H,30,32)/t15-,23+/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 100 mg/mL (209.PMID:25558565 86 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|AZD-9833 is extracted from patent US20180111931A1, example 17.|In Vivo:|AZD-9833 (oral administration; 0.2-50 mg/kg; 20 days) exhibits anti-tumour efficacy as a dose-dependent manner in human parental MCF7 mice xenograft. AZD-9833 (oral administration; 0.8-40 mg/kg; 30 days) decreases tumor growth as a dose-dependent manner. It gives almost complete tumour growth inhibition at the doses >10 mg/kg in mice.|Products are for research use only. Not for human use.|
