Product Name :
Epidermal growth factor receptor (994-1002) acetyl/amide
Description:
The epidermal growth factor receptor (EGFR; ErbB-1; HER1 inhumans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands1. EGFR (epidermal growth factor receptor) exists on the cell surface and is activated by binding of its specific ligands, including epidermal growth factor and transforming growth factor ǁ (TGFǁ). Mutations that lead to EGFR overexpression (known as upregulation) or overactivity have been associated with a number of cancers, including lung cancer, anal cancers and glioblastoma multiforme2. In this latter case a more or less specific mutation of EGFR, called EGFRvIII is often observed. Mutations, amplifications or misregulations of EGFR or family members are implicated in about 30% of all epithelial cancers. Mutations involving EGFR could lead to its constant activation, which could result in uncontrolled cell division – a predisposition for cancer. Consequently, mutations of EGFR have been identified in several types of cancer, and it is the target of an expanding class of anticancer therapies3.
CAS:
Molecular Weight:
1157.30
Formula:
C51H76N14O15S
Chemical Name:
3-[(1-{[1-({1-[(1-{[4-carbamimidamido-1-({1-[(1-{[1-carbamoyl-3-(methylsulfanyl)propyl]carbamoyl}-3-methylbutyl)carbamoyl]ethyl}carbamoyl)butyl]carbamoyl}-2-(4-hydroxyphenyl)ethyl)carbamoyl]-2-phenylethyl}carbamoyl)-2-carbamoylethyl]carbamoyl}-2-hydroxyethyl)carbamoyl]-3-acetamidopropanoic acid
Smiles :
CC(=O)NC(CC(O)=O)C(=O)NC(CO)C(=O)NC(CC(N)=O)C(=O)NC(CC1C=CC=CC=1)C(=O)NC(CC1C=CC(O)=CC=1)C(=O)NC(CCCNC(N)=N)C(=O)NC(C)C(=O)NC(CC(C)C)C(=O)NC(CCSC)C(N)=O
InChiKey:
SCMAKVKGJZYBIE-UHFFFAOYSA-N
InChi :
InChI=1S/C51H76N14O15S/c1-26(2)20-34(45(75)59-32(42(53)72)17-19-81-5)61-43(73)27(3)57-44(74)33(12-9-18-56-51(54)55)60-46(76)36(22-30-13-15-31(68)16-14-30)62-47(77)35(21-29-10-7-6-8-11-29)63-48(78)37(23-40(52)69)64-50(80)39(25-66)65-49(79)38(24-41(70)71)58-28(4)67/h6-8,10-11,13-16,26-27,32-39,66,68H,9,12,17-25H2,1-5H3,(H2,52,69)(H2,53,72)(H,57,74)(H,58,67)(H,59,75)(H,60,76)(H,61,73)(H,62,77)(H,63,78)(H,64,80)(H,65,79)(H,70,71)(H4,54,55,56)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
The epidermal growth factor receptor (EGFR; ErbB-1; HER1 inhumans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands1.{{Tiopronin} web|{Tiopronin} Purity & Documentation|{Tiopronin} Data Sheet|{Tiopronin} custom synthesis|{Tiopronin} Cancer} EGFR (epidermal growth factor receptor) exists on the cell surface and is activated by binding of its specific ligands, including epidermal growth factor and transforming growth factor ǁ (TGFǁ). Mutations that lead to EGFR overexpression (known as upregulation) or overactivity have been associated with a number of cancers, including lung cancer, anal cancers and glioblastoma multiforme2. In this latter case a more or less specific mutation of EGFR, called EGFRvIII is often observed. Mutations, amplifications or misregulations of EGFR or family members are implicated in about 30% of all epithelial cancers. Mutations involving EGFR could lead to its constant activation, which could result in uncontrolled cell division – a predisposition for cancer. Consequently, mutations of EGFR have been identified in several types of cancer, and it is the target of an expanding class of anticancer therapies3.|Product information|Molecular Weight: 1157.30|Formula: C51H76N14O15S|Chemical Name: 3-[(1-{[1-({1-[(1-{[4-carbamimidamido-1-({1-[(1-{[1-carbamoyl-3-(methylsulfanyl)propyl]carbamoyl}-3-methylbutyl)carbamoyl]ethyl}carbamoyl)butyl]carbamoyl}-2-(4-hydroxyphenyl)ethyl)carbamoyl]-2-phenylethyl}carbamoyl)-2-carbamoylethyl]carbamoyl}-2-hydroxyethyl)carbamoyl]-3-acetamidopropanoic acid|Smiles: CC(=O)NC(CC(O)=O)C(=O)NC(CO)C(=O)NC(CC(N)=O)C(=O)NC(CC1C=CC=CC=1)C(=O)NC(CC1C=CC(O)=CC=1)C(=O)NC(CCCNC(N)=N)C(=O)NC(C)C(=O)NC(CC(C)C)C(=O)NC(CCSC)C(N)=O|InChiKey: SCMAKVKGJZYBIE-UHFFFAOYSA-N|InChi: InChI=1S/C51H76N14O15S/c1-26(2)20-34(45(75)59-32(42(53)72)17-19-81-5)61-43(73)27(3)57-44(74)33(12-9-18-56-51(54)55)60-46(76)36(22-30-13-15-31(68)16-14-30)62-47(77)35(21-29-10-7-6-8-11-29)63-48(78)37(23-40(52)69)64-50(80)39(25-66)65-49(79)38(24-41(70)71)58-28(4)67/h6-8,10-11,13-16,26-27,32-39,66,68H,9,12,17-25H2,1-5H3,(H2,52,69)(H2,53,72)(H,57,74)(H,58,67)(H,59,75)(H,60,76)(H,61,73)(H,62,77)(H,63,78)(H,64,80)(H,65,79)(H,70,71)(H4,54,55,56)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Onvansertib} web|{Onvansertib} Polo-like Kinase (PLK)|{Onvansertib} Technical Information|{Onvansertib} Formula|{Onvansertib} manufacturer|{Onvansertib} Cancer} |Shelf Life: ≥12 months if stored properly.PMID:23695992 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
