Us [16], and S. coelicolor [17,18] are known to generate prodiginine pigments in
Us [16], and S. coelicolor [17,18] are identified to make prodiginine pigments along with several well-studied non-actinomycetes bacteria [1]. The biosynthetic pathway of prodigiosin has been well understood in Serratia marcescens [19,20] and amongst many other prodigiosin-producing bacterial species. S. marcescens synthesizes prodigiosin through 33 genes, whereas S. coelicolor utilizes only 23 genes to synthesize prodigiosin derivatives [19,21]. The red gene cluster biosynthesizes prodiginines in Telomerase custom synthesis Streptomyces species. Each Serratia and Streptomyces utilize 4-methoxy-2,2 bipyrrole-5-carbaldehyde to synthesize prodigiosin and undecylprodigiosin, correspondingly [19,20]. Although the genome contents of quite a few Streptomyces species happen to be reported inside the final decade [4,22], the genomes of red pigment-producing Streptomyces species, particularly marine Streptomyces, have stay largely uninvestigated, leaving a gap in the understanding of their evolutionary significances and drug discovery potential. Therefore, we intended to analyze and recognize the genome of prodigiosin-producing Streptomyces BSE6.1 isolated from a coastal sediment sample. Prodigiosin pigments are well known for their antimicrobial, anticancer, and cytotoxic properties [1,2,21,23]. Application of dried prodigiosin as a food-grade colorant in the improvement of prodigiosin coated microcapsules [24] and agar jellies [25] has been demonstrated from the extractions of S. marcescens [24], Zooshikella sp., and Streptomyces sp. [25]. Prodigiosin extracted from Streptomyces species has demonstrated promising antimicrobial activities against quite a few pathogenic microbes including Corynebacterium bovis, Mycobacterium smegmatis, Nocardia asteroids [7], and Staphylococcus aureus [7,25]. It can be believed that the combined activity of antimicrobial and meals colorant applications of prodigiosin would facilitate a synergistic impact in disease therapy. The present study introduces a novel species of a red-pigmented Streptomyces NOP Receptor/ORL1 Gene ID strain isolated from Andaman Islands, India’s marine atmosphere, and its genome for industrial and biotechnological applications. The preliminary research on prodigiosin-producing Streptomyces have demonstrated antimicrobial [7] and staining properties [8,25]. Despite the fact that a number of Streptomyces species are known to generate a wide array of pigment compounds [1,2], the production of prodiginine derivatives by a limited variety of Streptomyces species encouraged us to investigate the corresponding gene clusters within this Streptomyces sp. and compare it with other bacterial species. Andaman and Nicobar Islands are a chain of 836 Islands, like islands, islets and rocky outcrops, which can be pristine and unexplored for microbial sources. Bio-prospecting of microbial pigments from this atmosphere was initiated quite not too long ago [1,2,26]. The erratic weather circumstances observed within this geographically distinct location appear to favor a lot of novel pigmented microbes with possible biotechnological applications. For that reason, the present study explored the pigmented bacterial resources out there in the Andaman Islands and found a prospective Streptomyces sp. strain BSE6.1 with antibacterial and dye activity. As Andaman waters are nonetheless underexplored, we aimed to investigate the novelty of Streptomyces sp. strain BSE6.1 by means of whole-genome evaluation, predict the pigment gene clusters, and evaluate them with these of other Streptomyces species genomes readily available inside the public nucleotide databases.
