so be explored as a prospective therapeutic agent4 wholecentral nervous study, a 29-year-old male patient who had ingested about 3 to to treat walnuts (18 to program pathologies [11,14]. 28 g) presented unmotivated laughter, disorganized speech and psychomotor agitation, evolving to remission inside the following days. A different case study describes the intoxication two.2.aAntioxidant Activity 3-month-old infant who presented repeated episodes of afebrile of usually establishing α2β1 web status epilepticus research of antioxidant activity had been performed with myristicin isolated Investigation after ingestion of nutmeg. Phenytoin, phenobarbital and midazolam were administered to handle the seizures, and frompatient progressed to improvement, or present in extracts and vital oils obtained the the following plant species: Dorema with no new myristicin); Naturtium officinale (57 myristicin); Athamanta turbith (52 glabrum (14 epileptic episodes [11,14]. From Heracleum transcaucasicum and Heracleum anisactis (containing metabolites myristicin),these information, it truly is achievable to observe that myristicin and its active 96.87 and have psychoactive activity, which isMyristicaresponsible for its toxicity. Even so, because of 95.15 myristicin respectively) and primarily fragrans (containing eight to 11 myristicin) this activity, it might also be explored as a possible therapeutic agent to treat central nervous [162]. method pathologies [11,14]. The outcomes obtained showed that, in vivo, isolated myristicin (high purity) was ableto boost the concentration and activity of antioxidant enzymes: catalase, superoxide 2.two. Antioxidant Activity dismutase, glutathione peroxidase and glutathione reductase, also as decreasing the levelsInvestigation studies (Figure two). The vital oils containing myristicin also showed of lipid peroxidation of antioxidant activity had been carried out with myristicin isolatedantioxidant in extracts and vital oils obtained from the following plant species: fantastic or present activity in vitro, together with the exception on the oil in the plant Athamanta Dorema glabrum (14 was fairly low [162]. turbith, whose activity myristicin); Naturtium officinale (57 myristicin); Athamanta turbith (52 myristicin), Heracleum transcaucasicum and Heracleum anisactis (containing 96.87 and 95.15 myristicin respectively) and PPARγ Biological Activity Myristica fragrans (containing 8 to 11 myristicin) [162]. The outcomes obtained showed that, in vivo, isolated myristicin (high purity) was able to enhance the concentration and activity of antioxidant enzymes: catalase, superoxide dismutase, glutathione peroxidase and glutathione reductase, as well as decreasing the levels of lipid peroxidation (Figure two). The important oils containing myristicin also showed very good antioxidant activity in vitro, together with the exception on the oil in the plant Athamanta turbith, whose activity was comparatively low [162].Molecules 2021, 26, 5914 Molecules 2021, 26, x FOR PEER REVIEW4 ofof 16 4Figure two. Graphical representation with the anti-inflammatory, antiproliferative and antioxidant pathway mechanisms induced by myristicin. Figure 2. Graphical representation of your anti-inflammatory, antiproliferative and antioxidant pathway mechanisms induced by myristicin.One of the studies used Myristica fragrans (nutmeg) important oil containing myristicin, precisely the same oilof the research used Myristica fragrans (nutmeg) essential oil containing 1 devoid of myristicin, and also myristicin alone. As well as the antioxidant activity,
