Ci. 2021, 22,Int. J. Mol. Sci. 2021, 22,two of2 ofprogression of NAFLD, there is a possibility of transition to nonalcoholic steatohepatitis (NASH) and carcinoma (HCC) in the future [14]. As the worst the worst outcome of hepatocellularhepatocellular carcinoma (HCC) in the future [14]. Asoutcome of NAFLD, NAFLD, HCC connected linked with diabetes, suggesting can also be the precursor the HCC is strongly is strongly with diabetes, suggesting that NAFLD that NAFLD is also of precursor of T2D [15]. Consequently, targeting NAFLD has the potential to be T2D [15]. Consequently, targeting NAFLD has the possible to be a therapeutic strategya therapeutic strategy for MetS. for MetS. MetS also a a pathological condition, characterized by chronic, systemic, and lowMetS isis also pathological situation, characterized by chronic, systemic, and low-level level inflammation and imbalance [16,17]. By this, antioxidant antioxidant and antiinflammation and oxidativeoxidative imbalance [16,17]. By this, and anti-inflammatory inflammatory compounds might have advantageous effects on the onset and [18]. Organic compounds may have valuable effects around the onset and progression of MetSprogression of MetS [18]. are a class of biomolecules class of biomolecules with much more than 8000 species, polyphenolsNatural polyphenols are awidely located in plants, widely located in plants, with more than 8000 species, the majority of which exist in cocoa beans, sesame seeds, olives, wine, most of which exist in cocoa beans, nuts, Nav1.7 Antagonist manufacturer soybeans, olives, nuts, soybeans,tea, redsesame seeds, tea, and fruits [19]. Their structure [19]. Their structure is mainly characterized by vegetables, red wine, vegetables, and fruits is mainly characterized by containing 1 or containing 1 or extra phenolic groups, and can be basically divided into flavonoids and much more phenolic groups, and may be basically divided into flavonoids and non-flavonoids [20]. non-flavonoids [20]. Natural polyphenols typically have antioxidant and antiNatural polyphenols commonly have antioxidant and anti-inflammatory effects, each in vivo inflammatory effects, each in most of them also [21,22]. In addition, the majority of market and in vitro [21,22]. Additionally, vivo and in vitro strengthen blood vessel walls, them also gastrointestinal αLβ2 Antagonist list digestion, reduced blood lipids, avert atherosclerosis, decrease blood stress, strengthen blood vessel walls, promote gastrointestinal digestion, reduced blood lipids, improve human immunity, and inhibit the development of bacteria and cancer and inhibitAt avert atherosclerosis, lower blood pressure, enhance human immunity, cells [23]. the present, some epidemiological studies[23]. At present, some correlation involving polyphegrowth of bacteria and cancer cells have found a negative epidemiological studies have nol intake and thecorrelationof NAFLD and MetS [18,24]. Within this incidence of summarize identified a unfavorable incidence involving polyphenol intake and the context, we NAFLD and some organic polyphenols (such as summarize and non-flavonoids) that have been reMetS [18,24]. Within this context, we flavonoids some all-natural polyphenols (such as ported to beand non-flavonoids) which have been reported toof MetS and inside the prevention flavonoids involved within the prevention and management be involved its elements, and review the possible mechanisms and clinical and overview thethese organic compounds and management of MetS and its components, applications of attainable mechanisms and (Figure 1applications of those all-natural co.
