Will be the conventional pressing process. Inside the conventional R2R NIL pressing process, the bending on the roller is predicted through mathematical modeling and simulation (FEM). Via actual experiments, it was confirmed that the standard R2R NIL program includes a 1-Methylpyrrolidine custom synthesis non-uniform stress distribution at an 85 level during the pressing method around the make contact with location. Moreover, it was checked that the non-uniformity isn’t symmetrical, which signifies the other errors are engaged. A uniform pressing system was developed and implemented to execute pressing by person and distributed load. It was confirmed that the pressure distribution uniformity of the get in touch with area may be improved to a level of 33 by enhancing the bending of the roller through pressing the backup roller, which can be the core mechanism of this technique. Numerous backup rolls were utilized to improve the uniformity on the stress distribution, which was irregular as a result of other errors from skin, waviness error within the contact area and misalignment. The impact of each backup roller on the pressure distribution on the contact area was learned and analyzed working with regression analysis of supervised finding out, a machine finding out method. Applying the results of regression evaluation, the optimum force of each backup roller was identified. As a result of testing by applying the derived value, it was confirmed that the uniformity from the stress distribution on the speak to area is often enhanced to a degree of five . In this study, to use the machine understanding strategy (regression), the pressure distribution value in the make contact with region was divided into 3 sections and averaged. To extra closely measure the stress distribution in the actual get in touch with region, the typical interval required to become divided further. The proposed pressing system is developed to handle the non-uniformity from the contact pressure in actual time, but within this study, only the uniformity within the static state was studied. Inside the future, to Dipivefrin custom synthesis perform compensation control within a dynamic state, these improvements could be employed. In spite of your limitations in the strategy, it was confirmed that the non-uniformity with the pressing approach, one of many largest issues for increased productivity and yield in large-area R2R NIL, might be enhanced by applying the system created within this study. This strategy is expected to contribute to productivity and yield improvement in the NIL course of action.Author Contributions: Conceptualization, project administration, supervision, funding acquisition, writing–review and editing, S.K.; conceptualization, project administration, supervision, validation, writing–review and editing, M.G.L.; formal analysis, information curation, visualization, investigation, writing–original draft, G.E.K.; data curation, visualization, application, investigation, H.K.; investigation, formal evaluation, validation, K.W.; formal evaluation, investigation, Y.K.; validation, sources, S.-H.L.; project administration, validation, methodology, Y.J. All authors have study and agreed for the published version of your manuscript. Funding: This study is based on function supported by the Ministry of Trade, Market, and Power (MOTIE, Korea) beneath the Industrial Technology Innovation Applications (No. 20000665, No. N0002310); the National Study Foundation of Korea (NRF) funded by the Korean government (No. 2021M3H4A3A01050374, No. 2020M3H4A3106319). Institutional Critique Board Statement: Not applicable.Appl. Sci. 2021, 11,13 ofInformed Consent Statement: Not applicable. Data Avail.